Results 21 to 30 of about 65,102 (240)

Trained Immunity [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2021
Adaptive immune responses are characterized by antigen specificity and induction of lifelong immunologic memory. Recently, it has been reported that innate immune cells can also build immune memory characteristics—a process termed trained immunity. Trained immunity describes the persistent hyperresponsive phenotype that innate immune cells can develop ...
Tercan, H., Riksen, N.P., Joosten, L.A.B., Joosten, L.A.B., Netea, M.G., Bekkering, S., Bekkering, S.   +6 more
openaire   +3 more sources

Trained immunity and immune priming in plants and invertebrates. [PDF]

Elife
Immune memory has long been thought to be restricted to the adaptive immune system of vertebrates. However, several lines of evidence have changed our understanding of immune memory and have shattered the strict separation between innate and adaptive immunity.
Kurtz J, Andino R, Boraschi D, Contreras-Garduño J, Kachroo A, Khan I, Lanz Mendoza H, Mukherjee K, Peuß R, Ton J.   +9 more
europepmc   +4 more sources

DAMPs and Innate Immune Training [PDF]

Frontiers in Immunology, 2021
The ability to remember a previous encounter with pathogens was long thought to be a key feature of the adaptive immune system enabling the host to mount a faster, more specific and more effective immune response upon the reencounter, reducing the severity of infectious diseases.
Elisa Jentho, Elisa Jentho, Sebastian Weis, Sebastian Weis   +3 more
openaire   +3 more sources

Getting to the Marrow of Trained Immunity [PDF]

Epigenomics, 2018
Contains fulltext : 196392.pdf (Publisher’s version ) (Open Access)
Groh, L.A., Netea, M.G., Netea, M.G., Riksen, N.P., Keating, S.T.   +4 more
openaire   +3 more sources

Trained innate immunity and atherosclerosis [PDF]

Current Opinion in Lipidology, 2013
Monocytes/macrophages play a decisive role in the development and progression of atherosclerosis. It is currently unknown what stimuli initiate and orchestrate the activation of these cells in atherogenesis. In this review, we postulate that the novel concept of 'trained immunity' modulates the development and progression of atherosclerosis.Recently ...
Bekkering, S., Joosten, L.A.B., van der Meer, J.W.M., Netea, M.G., Riksen, N.P., Riksen, N.P.   +5 more
openaire   +3 more sources

β-Glucan-Induced Trained Immunity in Dogs

Frontiers in Immunology, 2020
Several observations in the world of comparative immunology in plants, insects, fish and eventually mammals lead to the discovery of trained immunity in the early 2010's. The first demonstrations provided evidence that innate immune cells were capable of
Simon Paris, Simon Paris, Simon Paris, Ludivine Chapat, Marion Pasin, Manon Lambiel, Thomas E. Sharrock, Rishabh Shukla, Cecile Sigoillot-Claude, Jeanne-Marie Bonnet, Hervé Poulet, Ludovic Freyburger, Karelle De Luca   +12 more
doaj   +1 more source

β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1

Viruses, 2023
Many studies have shown that β-glucan induces a trained immune phenotype in innate immune cells to defend against bacterial and fungal infections. The specific mechanism involves cellular metabolism and epigenetic reprogramming.
Guolei Wang, Zhiqiang Li, Mingfu Tian, Xianghua Cui, Jun’e Ma, Siyu Liu, Chenglin Ye, Li Yuan, Muhammad Suhaib Qudus, Uzair Afaq, Kailang Wu, Xinghui Liu, Chengliang Zhu   +12 more
doaj   +1 more source

Trained immunity in type 2 immune responses

Mucosal Immunology, 2022
Immunological memory of innate immune cells, also termed "trained immunity", allows for cross-protection against distinct pathogens, but may also drive chronic inflammation. Recent studies have shown that memory responses associated with type 2 immunity do not solely rely on adaptive immune cells, such as T- and B cells, but also involve the innate ...
Hartung, F., Esser-von Bieren, J.
openaire   +3 more sources

Trained immunity

Cell Host and Microbe, 2023
Trained immunity is a de facto memory for innate immune responses, leading to long-term functional reprogramming of innate immune cells. In physiological conditions, trained immunity leads to adaptive states that enhance resistance against pathogens and contributes to immunosurveillance.
Ziogas, Athanasios, Bruno, Mariolina, van der Meel, Roy, Mulder, Willem J.M., Netea, Mihai G.   +4 more
openaire   +1 more source

Trained immunity: implications for vaccination [PDF]

Current Opinion in Immunology, 2022
The concept that only adaptive immunity can build immunological memory has been challenged in the past decade. Live attenuated vaccines such as the Bacillus Calmette-Guérin, measles-containing vaccines, and the oral polio vaccine have been shown to reduce overall mortality beyond their effects attributable to the targeted diseases.
Geckin, Büsranur, Konstantin Föhse, Friedrich, Domínguez-Andrés, Jorge, Netea, Mihai G   +3 more
openaire   +2 more sources