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Innate immune cells: Key players of orchestra in modulating tumor microenvironment (TME) [PDF]

Heliyon
The tumor microenvironment (TME) with vital role in cancer progression is composed of various cells such as endothelial cells, immune cells, and mesenchymal stem cells.
Mahvash Sadeghi, Sajad Dehnavi, Moosa Sharifat, Amir Mohammad Amiri, Ali Khodadadi   +4 more
doaj   +4 more sources

Ambivalent roles of miRNAs in cancer development via modulating tumor-associated innate immune cells [PDF]

BioImpacts
The tumor microenvironment (TME), comprising malignant and non-transformed cells like immune cells, endothelial cells, and cancer-associated fibroblasts, significantly affects tumor growth and progression.
Bahar Naseri, Amirhossein Mardi, Najibeh Shekari, Neda Shajari, Samin Abdolzadeh, Hossein Khorramdelazad, Amirhossein Hatami-Sadr, Milad Taghizadeh Anvar, Mohammad Reza Javan, Amirhossein Heibatollahi, Javad Masoumi, Farid Ghorbaninezhad, Behzad Baradaran   +12 more
doaj   +2 more sources

Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy

Biomedicines, 2022
Innate immunity is critical for immediate recognition and elimination of invading pathogens or defense against cancer cell growth. Dysregulation of innate immune systems is associated with the pathogenesis of different types of inflammatory diseases ...
Shengyuan Zhao, Samy L. Habib, Alireza G. Senejani, Manu Sebastian, Dawit Kidane   +4 more
doaj   +1 more source

Determinants of Innate Immunity in Visceral Leishmaniasis and Their Implication in Vaccine Development

Frontiers in Immunology, 2021
Leishmaniasis is endemic to the tropical and subtropical regions of the world and is transmitted by the bite of an infected sand fly. The multifaceted interactions between Leishmania, the host innate immune cells, and the adaptive immunity determine the ...
Greta Volpedo, Thalia Pacheco-Fernandez, Parna Bhattacharya, Timur Oljuskin, Ranadhir Dey, Sreenivas Gannavaram, Abhay R. Satoskar, Hira L. Nakhasi   +7 more
doaj   +1 more source

Role of innate immune cells in multiple sclerosis [PDF]

Frontiers in Immunology
Carolina Prado, Noelia Escobedo, Andres A Herrada   +2 more
exaly   +2 more sources

Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes

Frontiers in Immunology, 2023
The large majority of lymphocytes belong to the adaptive immune system, which are made up of B2 B cells and the αβ T cells; these are the effectors in an adaptive immune response.
Sebastian Joyce, Sebastian Joyce, Gosife Donald Okoye, John P. Driver   +3 more
doaj   +1 more source

The role of innate immune cells in the tumor microenvironment and research progress in anti-tumor therapy

Frontiers in Immunology, 2023
Innate immune cells in the tumor microenvironment (TME) mainly include macrophages, neutrophils, natural killer cells, dendritic cells and bone marrow derived suppressor cells.
Chenglin Lu, Ying Liu, Ying Liu, Nasra Mohamoud Ali, Bin Zhang, Xiaonan Cui   +5 more
doaj   +1 more source

Deciphering Innate Immune Cell-Tumor Microenvironment Crosstalk at a Single-Cell Level

Frontiers in Cell and Developmental Biology, 2022
The tumor microenvironment encompasses various innate immune cells which regulate tumor progression. Exploiting innate immune cells is a new frontier of cancer immunotherapy.
Ryohichi Sugimura, Yiming Chao
doaj   +1 more source

Innate-adaptive immunity interplay and redox regulation in immune response

Redox Biology, 2020
Innate and adaptive immune cell activation and infiltration is the key characteristic of tissue inflammation. The innate immune system is the front line of host defense in which innate immune cells are activated by danger signals, including pathogen- and
Lizhe Sun, Xianwei Wang, Jason Saredy, Zuyi Yuan, Xiaofeng Yang, Hong Wang   +5 more
doaj   +1 more source

Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals

Frontiers in Microbiology, 2020
Microsporidia are obligate intracellular and eukaryotic pathogens that can infect immunocompromised and immunocompetent mammals, including humans. Both innate and adaptive immune systems play important roles against microsporidian infection.
Yinze Han, Yinze Han, Hailong Gao, Hailong Gao, Jinzhi Xu, Jinzhi Xu, Jian Luo, Jian Luo, Bing Han, Jialing Bao, Jialing Bao, Guoqing Pan, Guoqing Pan, Tian Li, Tian Li, Zeyang Zhou, Zeyang Zhou, Zeyang Zhou   +17 more
doaj   +1 more source