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Innate Immunity: NKT Cells in the Spotlight [PDF]
Current Biology, 2005 Cells of the innate immune system provide a first line of defense against microbial invaders. Recent studies have revealed how one intriguing member of the innate immune system, the natural killer T cell, is activated during bacterial infections.
Van Kaer, Luc, Joyce, Sebastian
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Autophagy, the innate immune response and cancer
Molecular Oncology, 2020 Autophagy is a cellular degradation and recycling system, which can interact with components of innate immune signalling pathways to enhance pathogen clearance, in both immune and nonimmune cells.
Chelsea Gerada, Kevin M. Ryan
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Modulation by luminal factors on the functions and migration of intestinal innate immunity
Frontiers in Immunology, 2023 Luminal antigens, nutrients, metabolites from commensal bacteria, bile acids, or neuropeptides influence the function and trafficking of immune cells in the intestine.
Masaaki Higashiyama +2 more
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Frontiers in Physiology, 2020 Oncolytic viruses are of growing interest to cancer researchers and clinicians, due to their selectivity for tumor cells over healthy cells and their immunostimulatory properties.
Kathleen M. Storey +2 more
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Akt isoforms in the immune system
Frontiers in Immunology, 2022 Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt’s expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system.
Mireia Guerau-de-Arellano +7 more
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Innate Immune Cells in Inflammation and Cancer [PDF]
Cancer Immunology Research, 2013 Abstract The innate immune system has evolved in multicellular organisms to detect and respond to situations that compromise tissue homeostasis. It comprises a set of tissue-resident and circulating leukocytes primarily designed to sense pathogens and tissue damage through hardwired receptors and eliminate noxious sources by mediating ...
Roni, Nowarski +3 more
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Journal of Immunology Research, 2015 Tuberculosis (TB) remains a serious global public health problem that results in up to 2 million deaths each year. TB is caused by the human pathogen, Mycobacterium tuberculosis (Mtb), which infects primarily innate immune cells patrolling the lung ...
Jonathan Kevin Sia +2 more
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Osteoclasts—the innate immune cells of the bone
Autoimmunity, 2008 Osteopenia and periarticular bony erosion are consequences of chronic inflammatory autoimmune disease due to an imbalance of osteoclast activity relative to new bone formation. Osteoclasts, which are specialized as the only bone resorbing cell type, are differentiated from hematopoietic myeloid precursor cells. Inflammatory signals mediated by multiple
Yalei, Wu +2 more
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CD90+ stromal cells are non-professional innate immune effectors of the human colonic mucosa
Frontiers in Immunology, 2013 Immune responses at the intestinal mucosa must allow for host protection whilst simultaneously avoiding inappropriate inflammation. Although much work has focused on the innate immune functionality of hematopoietic immune cells, non-hematopoietic cell ...
Benjamin M J Owens +8 more
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Role of Innate lymphocytes in infection and inflammation
Frontiers in Immunology, 2012 Cooperation of innate and adaptive immune responses is critical for the protective immunity against various invading microbes. Distinct types of effector T cells play different roles in adaptive immune responses.
Shigeo eKoyasu, Kazuyo eMoro
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