Results 31 to 40 of about 5,833,650 (299)

Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy

Journal of Immunology Research, 2020
Innate immunity represents the first barrier for host defense against microbial infection. Toll-like receptors (TLRs) are the most well-defined PRRs with respect to PAMP recognition and induction of innate immune responses.
Ji-Yoon Noh, Suk Ran Yoon, Tae-Don Kim, Inpyo Choi, Haiyoung Jung   +4 more
doaj   +1 more source

Innate immunity and immunotherapy for hemorrhagic shock

Frontiers in Immunology, 2022
Hemorrhagic shock (HS) is a shock result of hypovolemic injury, in which the innate immune response plays a central role in the pathophysiology ofthe severe complications and organ injury in surviving patients.
Qingxia Huang, Qingxia Huang, Song Gao, Yao Yao, Yisa Wang, Jing Li, Jinjin Chen, Chen guo, Daqing Zhao, Xiangyan Li   +9 more
doaj   +1 more source

Innate Immunity: NKT Cells in the Spotlight [PDF]

Current Biology, 2005
Cells of the innate immune system provide a first line of defense against microbial invaders. Recent studies have revealed how one intriguing member of the innate immune system, the natural killer T cell, is activated during bacterial infections.
Van Kaer, Luc, Joyce, Sebastian
openaire   +2 more sources

Curating the innate immunity interactome [PDF]

, 2010
peer-reviewedBackground: The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks.
Laird, Matthew R, Anastasia Sribnaia, Winsor, Geoffrey L., Lynn, David J, Giselle Ring, Foroushani, Amir K., Laird, Matthew R., Que, Jaimmie, Geoffrey L Winsor, Robert EW Hancock, Sribnaia, Anastasia, Hancock, Robert E.W., Ring, Giselle, Melissa Yau, Fiona SL Brinkman, Calvin Chan, Jaimmie Que, David J Lynn, Brinkman, Fiona S. L., Naseer, Misbah, Matthew R Laird, Yau, Melissa, Lo, Raymond, Raymond Lo, Chan, Calvin, Wee, Kathleen, Winsor, Geoffrey L, Breuer, Karin, Kathleen Wee, Amir K Foroushani, Hancock, R. E. W. (Robert E. W.), Brinkman, Fiona S., Misbah Naseer, Karin Breuer, Lynn, David J.   +34 more
core   +1 more source

Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]

, 2008
Alum is used as a vaccine adjuvant and induces T_h2 responses and T_h2-driven antibody isotype production against co-injected antigens.
White, Janice, Kappler, John W., McKee, Amy S., Marrack, Philippa, Macleod, Megan, P. Marrack, J. White, J. W. Kappler, F. Crawford, A. S. McKee, M. MacLeod, Crawford, Frances   +11 more
core   +1 more source

Autophagy, the innate immune response and cancer

Molecular Oncology, 2020
Autophagy is a cellular degradation and recycling system, which can interact with components of innate immune signalling pathways to enhance pathogen clearance, in both immune and nonimmune cells.
Chelsea Gerada, Kevin M. Ryan
doaj   +1 more source

Akt isoforms in the immune system

Frontiers in Immunology, 2022
Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt’s expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system.
Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Zayda L. Piedra-Quintero, Philip N. Tsichlis, Philip N. Tsichlis   +7 more
doaj   +1 more source

Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis [PDF]

, 2004
Streptococcus uberis and Serratia marcescens are Gram-positive and Gram-negative bacteria, respectively, that induce clinical mastitis. Once initial host barrier systems have been breached by these pathogens, the innate immune system provides the next ...
Bannerman, Douglas, Goff, JP, Goff, Jesse P, Lippolis, JD, John D. Lippolis, Paape, Max, Bannerman, Douglas D, Paape, Max J, Kimura, K, Jayne C. Hope, Hope, Jayne C, Kimura, Kayoko, Lippolis, John D, Douglas D. Bannerman, Max J. Paape, Lippolis, John, Hope, Jayne, Kayoko Kimura, Hope, Jayne; id_orcid, Jesse P. Goff, Goff, Jesse   +20 more
core   +1 more source

Stretching the Function of Innate Immune Cells [PDF]

Frontiers in Immunology, 2021
The importance of innate immune cells to sense and respond to their physical environment is becoming increasingly recognized. Innate immune cells (e.g. macrophages and neutrophils) are able to receive mechanical signals through several mechanisms.
Erica M. Orsini, Apostolos Perelas, Brian D. Southern, Brian D. Southern, Lisa M. Grove, Mitchell A. Olman, Mitchell A. Olman, Rachel G. Scheraga, Rachel G. Scheraga   +8 more
openaire   +3 more sources

Determinants of innate immune responses to mycobacteria [PDF]

, 2012
Includes bibliographical references.Innate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers.
Shey, Muki Shehu
core   +1 more source