Results 41 to 50 of about 712,793 (257)

Emerging Concepts in Innate Lymphoid Cells, Memory, and Reproduction

Frontiers in Immunology, 2022
Members of the innate immune system, innate lymphoid cells (ILCs), encompass five major populations (Natural Killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer cells) whose functions include defense against pathogens, surveillance of ...
Rodolfo R. Favaro, Katherine Phillips, Romane Delaunay-Danguy, Kaja Ujčič, Udo R. Markert   +4 more
doaj   +1 more source

Role of Innate Immune Cells in Psoriasis [PDF]

International Journal of Molecular Sciences, 2020
Psoriasis is a chronic inflammatory skin condition caused by a combination of hereditary and environmental factors. Its development is closely related to the adaptive immune response. T helper 17 cells are major IL-17-producing cells, a function that plays an important role in the pathogenesis of psoriasis.
Sato, Yuki, Ogawa, Eisaku, Okuyama, Ryuhei   +2 more
openaire   +2 more sources

Targeting Innate Immunity to Enhance the Efficacy of Radiation Therapy

Frontiers in Immunology, 2019
Radiation continues to play a major role in the treatment of almost every cancer type. Traditional radiation studies focused on its ability to damage DNA, but recent evidence has demonstrated that a key mechanism driving the efficacy of radiation in vivo
Tahir B. Dar, Regina M. Henson, Stephen L. Shiao, Stephen L. Shiao   +3 more
doaj   +1 more source

Innate immunity and early liver inflammation

Frontiers in Immunology, 2023
The innate system constitutes a first-line defence mechanism against pathogens. 80% of the blood supply entering the human liver arrives from the splanchnic circulation through the portal vein, so it is constantly exposed to immunologically active ...
Jordi Yang Zhou, Jordi Yang Zhou
doaj   +1 more source

Innate Immune Cells Speak Manganese [PDF]

Immunity, 2018
Some metal ions, such as Ca2+ and Zn2+, are involved in intracellular communication in immune cells by acting as second messengers. In this issue of Immunity, Wang et al. (2018) present findings implying a similar role for an additional metal ion, by showing that manganese participates in the recognition of cytoplasmic DNA.
openaire   +2 more sources

Role of Innate Immune Cells in the Control of Influenza A Virus Infection

Al-SalamJournal for Medical Science
In human immune response against invading viruses, the innate immune system plays a critical role in the early defense towards variable viral infections before the adaptive immune response triggered, particularly against influenza viruses, like with ...
Marwa Lafta Jabur, Eman A. Muhsin, Shahrazad Ahmed Khalaf   +2 more
doaj   +1 more source

Direct interaction studies between Aspergillus fumigatus and Human immune cells; what have we learned about pathogenicity and host immunity?

Frontiers in Microbiology, 2012
Invasive aspergillosis is a significant threat to health and is a major cause of mortality in immunocompromised individuals. Understanding the interaction between the fungus and the immune system is important in determining how the immunocompetent host ...
Charles Oliver Morton, Maria eBouzani, Juergen eLoeffler, Thomas Richard Rogers   +3 more
doaj   +1 more source

Tim-3: An activation marker and activation limiter of innate immune cells

Frontiers in Immunology, 2013
Tim-3 was initially identified on activated Th1, Th17, and Tc1 cells and induces T cell death or exhaustion after binding to its ligand, Gal-9. The observed relationship between dysregulated Tim-3 expression on T cells and the progression of many ...
Gencheng eHan, Guojiang eChen, Beifen eShen, Yan eLi   +3 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Innate Lymphoid Cells in Mucosal Immunity [PDF]

Frontiers in Immunology, 2019
Innate lymphoid cells (ILCs) are innate counterparts of T cells that contribute to immune responses by secreting effector cytokines and regulating the functions of other innate and adaptive immune cells. ILCs carry out some unique functions but share some tasks with T cells.
Panda, Santosh K, Colonna, Marco
openaire   +4 more sources