Results 61 to 70 of about 712,793 (257)

Innate immunity in tumors: roles and therapeutic targets

Frontiers in Immunology
Innate immune cells and pathways are central to shaping the tumor microenvironment (TME), where they influence tumor growth, metastasis, and responsiveness to immunotherapy.
Songze Leng, Songze Leng, Yuyue Ren, Yuyue Ren, Yaoyao Tian, Weiwei Zhao, Yue Mou, Yue Mou, Xingyu Chen, Xingyu Chen, Hong Zhou, Hong Zhou, Wei Wang, Wei Wang   +13 more
doaj   +1 more source

Close encounters of lymphoid cells and bacteria

Frontiers in Immunology, 2016
During infections, the first reaction of the host against microbial pathogens is carried out by innate immune cells, which recognize conserved structures on pathogens, called pathogen-associated molecular patterns (PAMPs).
Aranzazu Cruz-Adalia, Esteban Veiga
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation

Mediators of Inflammation, 2016
Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
Kathleen L. McCoy
doaj   +1 more source

Innate Immune Cells' Contribution to Systemic Lupus Erythematosus

Frontiers in Immunology, 2019
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, immune complex deposition, and tissue damage in the kidneys, skin, heart and lung. Because of the pathogenic role
Andrés A. Herrada, Noelia Escobedo, Mirentxu Iruretagoyena, Rodrigo A. Valenzuela, Rodrigo A. Valenzuela, Paula I. Burgos, Loreto Cuitino, Loreto Cuitino, Carolina Llanos   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Innate lymphoid cells in antitumor immunity

Journal of Leukocyte Biology, 2017
Abstract Innate lymphoid cells (ILCs) are the most recently characterized subset of innate lymphocytes. Based on their specific transcriptional regulation, cytokine secretion pattern and effector functions ILCs mirror the different CD4 T helper cell subsets, with the unique attributes of acting locally in early phases of immune responses,
Salomé, Bérengère, Jandus, Camilla
openaire   +3 more sources

Phospholipid signaling in innate immune cells [PDF]

Journal of Clinical Investigation, 2018
Phospholipids comprise a large body of lipids that define cells and organelles by forming membrane structures. Importantly, their complex metabolism represents a highly controlled cellular signaling network that is essential for mounting an effective innate immune response.
Valerie B. O’Donnell, Jamie Rossjohn, Michael J.O. Wakelam   +2 more
openaire   +3 more sources

Innate immune activation in vitiligo: mechanisms and pathophysiological implications

Frontiers in Immunology
Vitiligo is an autoimmune disease characterized by the progressive destruction of epidermal melanocytes, leading to skin depigmentation. Although significant advances have been made in understanding the pathogenesis of vitiligo, the intricate interplay ...
Yuting Wang, Junhua Cao, Xiaomin Liu, Chengcheng Xiong, Da Xu, Fang Bian   +5 more
doaj   +1 more source