Results 41 to 50 of about 1,089,122 (265)

Bacillus Calmette–Guérin Immunotherapy for Cancer

Vaccines, 2021
Bacillus Calmette–Guérin (BCG), an attenuated vaccine from Mycobacterium bovis, was initially developed as an agent for vaccination against tuberculosis.
Fabíola Cardillo, Maiara Bonfim, Periela da Silva Vasconcelos Sousa, José Mengel, Luiz Roberto Ribeiro Castello-Branco, Rosa Teixeira Pinho   +5 more
doaj   +1 more source

Trained immunity

Cell Host and Microbe, 2023
Trained immunity is a de facto memory for innate immune responses, leading to long-term functional reprogramming of innate immune cells. In physiological conditions, trained immunity leads to adaptive states that enhance resistance against pathogens and contributes to immunosurveillance.
Ziogas, Athanasios, Bruno, Mariolina, van der Meel, Roy, Mulder, Willem J.M., Netea, Mihai G.   +4 more
openaire   +1 more source

Trained immunity in atherosclerotic cardiovascular disease [PDF]

Nature Reviews Cardiology, 2021
Atherosclerosis is characterized by incessant inflammation in the arterial wall in which monocytes and macrophages play a crucial role. During the past few years, it has been reported that cells from the innate immune system can develop a long-lasting proinflammatory phenotype after brief stimulation not only with microbial products but also endogenous
Flores Gomez, D., Bekkering, S., Bekkering, S., Netea, M.G., Riksen, N.P.   +4 more
openaire   +7 more sources

Hypothetical Immunological and Immunogenetic Model of Heterogenous Effects of BCG Vaccination in SARS-CoV-2 Infections: BCG-induced Trained and Heterologous Immunity

Journal of Medical Science, 2021
Though SARS-CoV-2 infections are yet to be completely characterised in a host-pathogen interaction context, some of the mechanisms governing the interaction between the novel betacoronavirus and the human host, have been brought to light in satisfactory ...
Dženan Kovačić, Andrej A. Gajić, Dado Latinović, Adna Softić   +3 more
doaj  

Bibliometric and Visual Analysis of Trained Immunity from 2005 to 2024. [PDF]

J Inflamm Res
Zhengang Yang,1,* Jingxia Hu,2,* Li Kang,2 Hao He2 1Department of Otolaryngology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, People’s Republic of China; 2Department of Immunology, Shandong First ...
Yang Z, Hu J, Kang L, He H.
europepmc   +2 more sources

Trained immunity modulates inflammation-induced fibrosis

Nature Communications, 2019
Innate immune cells can be trained by some stimuli or pathogen exposures to be metabolically and epigenetically altered such that they have different responses to subsequent exposures.
Mohamed Jeljeli, Luiza Gama Coelho Riccio, Ludivine Doridot, Charlotte Chêne, Carole Nicco, Sandrine Chouzenoux, Quentin Deletang, Yannick Allanore, Niloufar Kavian, Frédéric Batteux   +9 more
doaj   +1 more source

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection [PDF]

, 2020
Contains fulltext : 220579.pdf (Publisher’s version ) (Open Access)SARS-CoV-2 infection is mild in the majority of individuals but progresses into severe pneumonia in a small proportion of patients.
Netea, Mihai G, van Crevel, Reinout, Dominguez Andres, J., Domínguez-Andrés, Jorge, Dominguez-Andres, J, Crevel, R. van, Giamarellos-Bourboulis, E.J., Netea, M.G., Netea, MG, van de Veerdonk, FL, van Crevel, R, Bonten, Marc, Veerdonk, F.L. van de, Bonten, M, van de Veerdonk, Frank L, Bonten, M., Curtis, N, Curtis, N., Giamarellos-Bourboulis, EJ, Curtis, Nigel, Giamarellos-Bourboulis, Evangelos J   +20 more
core   +1 more source

Advances in immune response to pulmonary infection: Nonspecificity, specificity and memory

Chronic Diseases and Translational Medicine, 2023
The lung immune response consists of various cells involved in both innate and adaptive immune processes. Innate immunity participates in immune resistance in a nonspecific manner, whereas adaptive immunity effectively eliminates pathogens through ...
Jianqiao Xu, Lixin Xie
doaj   +1 more source

Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis

Frontiers in Immunology, 2022
Aging plays a critical role in the incidence and severity of infection, with age emerging as an independent predictor of mortality in sepsis. Trained immunity reprograms immunocytes to respond more rapidly and effectively to pathogens and serves as a ...
P. Spencer Gill, P. Spencer Gill, Tammy R. Ozment, Tammy R. Ozment, Nicole H. Lewis, Edward R. Sherwood, Edward R. Sherwood, David L. Williams, David L. Williams   +8 more
doaj   +1 more source

Trained immunity and immune priming in plants and invertebrates. [PDF]

Elife
Immune memory has long been thought to be restricted to the adaptive immune system of vertebrates. However, several lines of evidence have changed our understanding of immune memory and have shattered the strict separation between innate and adaptive immunity.
Kurtz J, Andino R, Boraschi D, Contreras-Garduño J, Kachroo A, Khan I, Lanz Mendoza H, Mukherjee K, Peuß R, Ton J.   +9 more
europepmc   +4 more sources