Results 41 to 50 of about 65,102 (240)

Trained immunity in organ transplantation [PDF]

American Journal of Transplantation, 2020
Consistent induction of donor-specific unresponsiveness in the absence of continuous immunosuppressive therapy and toxic effects remains a difficult task in clinical organ transplantation. Transplant immunologists have developed numerous experimental treatments that target antigen-presentation (signal 1), costimulation (signal 2), and cytokine ...
Ochando, J., Fayad, Z.A., Madsen, J.C., Netea, M.G., Netea, M.G., Mulder, W.J.   +5 more
openaire   +6 more sources

Lnc-ing Trained Immunity to Chromatin Architecture

Frontiers in Cell and Developmental Biology, 2019
Human innate immune cells exposed to certain infections or stimuli develop enhanced immune responses upon re-infection with a different second stimulus, a process termed trained immunity.
Stephanie Fanucchi, Stephanie Fanucchi, Musa M. Mhlanga   +2 more
doaj   +1 more source

The Role of Cell Metabolism in Innate Immune Memory

Journal of Innate Immunity, 2020
Immunological memory is classically attributed to adaptive immune responses, but recent studies have shown that challenged innate immune cells can display long-term functional changes that increase nonspecific responsiveness to subsequent infections ...
Anaisa Valido Ferreira, Jorge Domiguéz-Andrés, Mihai Gheorghe Netea   +2 more
doaj   +1 more source

Innate immune memory, trained immunity and nomenclature clarification [PDF]

Nature Immunology, 2023
Contains fulltext : 295907.pdf (Publisher’s version ) (Open Access)
George Hajishengallis, Mihai G. Netea, Triantafyllos Chavakis   +2 more
openaire   +3 more sources

Induction of Trained Immunity by Recombinant Vaccines

Frontiers in Immunology, 2021
Vaccines represent an important strategy to protect humans against a wide variety of pathogens and have even led to eradicating some diseases. Although every vaccine is developed to induce specific protection for a particular pathogen, some vaccine ...
Camila Covián, Mariana Ríos, Roslye V. Berríos-Rojas, Susan M. Bueno, Alexis M. Kalergis, Alexis M. Kalergis   +5 more
doaj   +1 more source

Innate Immune Pathways in Atherosclerosis—From Signaling to Long-Term Epigenetic Reprogramming

Cells, 2023
Innate immune pathways play a crucial role in the development of atherosclerosis, from sensing initial danger signals to the long-term reprogramming of immune cells.
Arailym Aronova, Federica Tosato, Nawraa Naser, Yaw Asare   +3 more
doaj   +1 more source

Lactate trains immunity

Trends in Immunology
Understanding the mechanisms implicated in the establishment of trained immunity could aid the design of novel therapeutic approaches. By studying Bacille Calmette-Guerin (BCG) vaccination in a human cohort, Ziogas and colleagues demonstrate the role of lactate generation and its use for histone lactylation as a key mechanism for establishing innate ...
Alba Llibre, Claudio Mauro
openaire   +2 more sources

Immunization Training: Right or Privilege? [PDF]

American Journal of Pharmaceutical Education, 2012
Immunization training in US colleges and schools of pharmacy has progressed quickly and significantly. The first formal national training and certificate program aimed at pharmacists was introduced by the American Pharmacists Association in 1996 and was quickly adopted as a curricular model and component by many colleges and schools.1-3 The 1990s also ...
Frank, Romanelli, Trish, Freeman
openaire   +2 more sources

Trained Immunity Confers Prolonged Protection From Listeriosis

Frontiers in Immunology, 2021
Trained immunity refers to the ability of the innate immune system exposed to a first challenge to provide an enhanced response to a secondary homologous or heterologous challenge. We reported that training induced with β-glucan one week before infection
Charlotte Théroude, Marta Reverte, Tytti Heinonen, Eleonora Ciarlo, Irene T. Schrijver, Nikolaos Antonakos, Nicolas Maillard, Florian Pralong, Didier Le Roy, Thierry Roger   +9 more
doaj   +1 more source

Trained immunity in the pathogenesis of vitiligo

Pigment Cell & Melanoma Research, 2023
AbstractVitiligo is caused by an autoimmune reaction against melanocytes leading to melanocyte loss. The cause of vitiligo is an interaction between genetic susceptibility and environmental factors. Both the adaptive immune system—through cytotoxic CD8+ T cells and melanocyte specific antibodies—and the innate immune system are involved in these immune
Nicoline F. Post, Greta Ginski, Rens Peters, Nathalie O. P. Van Uden, Marcel W. Bekkenk, Albert Wolkerstorfer, Mihai G. Netea, Rosalie M. Luiten   +7 more
openaire   +3 more sources