Results 31 to 40 of about 65,102 (240)
Bacillus Calmette–Guérin Immunotherapy for Cancer
Vaccines, 2021 Bacillus Calmette–Guérin (BCG), an attenuated vaccine from Mycobacterium bovis, was initially developed as an agent for vaccination against tuberculosis.
Fabíola Cardillo +5 more
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Trained immunity: A Yin‐Yang balance
MedComm, 2022 Traditionally, immune memory is regarded as an exclusive hallmark of adaptive immunity. However, a growing body of evidence suggesting that innate immune cells show adaptive characteristics has challenged this dogma. In the past decade, trained immunity,
Zhidong Hu +3 more
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Therapeutic targeting of trained immunity [PDF]
Nature Reviews Drug Discovery, 2019 Immunotherapy is revolutionizing the treatment of diseases in which dysregulated immune responses have an important role. However, most of the immunotherapy strategies currently being developed engage the adaptive immune system. In the past decade, both myeloid (monocytes, macrophages and dendritic cells) and lymphoid (natural killer cells and innate ...
Willem J. M. Mulder +4 more
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Trained immunity in atherosclerotic cardiovascular disease [PDF]
Nature Reviews Cardiology, 2021 Atherosclerosis is characterized by incessant inflammation in the arterial wall in which monocytes and macrophages play a crucial role. During the past few years, it has been reported that cells from the innate immune system can develop a long-lasting proinflammatory phenotype after brief stimulation not only with microbial products but also endogenous
Flores Gomez, D. +4 more
openaire +7 more sources
Journal of Medical Science, 2021 Though SARS-CoV-2 infections are yet to be completely characterised in a host-pathogen interaction context, some of the mechanisms governing the interaction between the novel betacoronavirus and the human host, have been brought to light in satisfactory ...
Dženan Kovačić +3 more
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Trained immunity modulates inflammation-induced fibrosis
Nature Communications, 2019 Innate immune cells can be trained by some stimuli or pathogen exposures to be metabolically and epigenetically altered such that they have different responses to subsequent exposures.
Mohamed Jeljeli +9 more
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The role of neutrophils in trained immunity
Immunological Reviews, 2022 SummaryThe principle of trained immunity represents innate immune memory due to sustained, mainly epigenetic, changes triggered by endogenous or exogenous stimuli in bone marrow (BM) progenitors (central trained immunity) and their innate immune cell progeny, thereby triggering elevated responsiveness against secondary stimuli.
Kalafati, Lydia +3 more
openaire +4 more sources
Advances in immune response to pulmonary infection: Nonspecificity, specificity and memory
Chronic Diseases and Translational Medicine, 2023 The lung immune response consists of various cells involved in both innate and adaptive immune processes. Innate immunity participates in immune resistance in a nonspecific manner, whereas adaptive immunity effectively eliminates pathogens through ...
Jianqiao Xu, Lixin Xie
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Trained innate immunity, epigenetics, and food allergy
Frontiers in Allergy, 2023 In recent years the increased incidence of food allergy in Western culture has been associated with environmental factors and an inappropriate immune phenotype.
Llilian Arzola-Martínez +5 more
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Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis
Frontiers in Immunology, 2022 Aging plays a critical role in the incidence and severity of infection, with age emerging as an independent predictor of mortality in sepsis. Trained immunity reprograms immunocytes to respond more rapidly and effectively to pathogens and serves as a ...
P. Spencer Gill +8 more
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