Results 31 to 40 of about 1,089,122 (265)

Regulating trained immunity with nanomedicine [PDF]

, 2022
Trained immunity refers to a hyperresponsive functional state of the innate immune system, which is induced by certain stimuli, such as infections or vaccination.
Beldman, Thijs J., Mulder, Willem J. M., van Leent, Mandy M.T., Mulder, Willem J.M., de Dreu, Anne, Schrijver, David P.; id_orcid, Priem, Bram, Netea, Mihai G., Hofstraat, Stijn R. J., Zwolsman, Robby, van Leent, Mandy M. T., Schrijver, David P., de Dreu, Anne; id_orcid, Hofstraat, Stijn R.J.   +13 more
core   +2 more sources

Trained Immunity [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2021
Adaptive immune responses are characterized by antigen specificity and induction of lifelong immunologic memory. Recently, it has been reported that innate immune cells can also build immune memory characteristics—a process termed trained immunity. Trained immunity describes the persistent hyperresponsive phenotype that innate immune cells can develop ...
Tercan, H., Riksen, N.P., Joosten, L.A.B., Joosten, L.A.B., Netea, M.G., Bekkering, S., Bekkering, S.   +6 more
openaire   +3 more sources

Trained Immunity in Primary Sjögren’s Syndrome: Linking Type I Interferons to a Pro-Atherogenic Phenotype [PDF]

, 2022
BACKGROUND: Trained immunity – or innate immune memory – can be described as the long-term reprogramming of innate immune cells towards a hyperresponsive state which involves intracellular metabolic changes.
Grashof, Dwin G. B., Kamphuis, Sylvia, Tarn, Jessica R., Huijser, Erika, Lopes, Ana P., Versnel, Marjan A., van de Werken, Harmen J. G., van Daele, Paul L. A., Brkic, Zana; id_orcid, van Roon, Joel A. G., Dik, Willem A., Grashof, Dwin G.B., van de Werken, Harmen J.G.; id_orcid, Ng, Wan Fai, van Daele, Paul L.A., Huisman, Josje M. A., Wahadat, M. Javad, Brkic, Zana, Joosten, Leo A. B., van de Werken, Harmen J.G., Huisman, Josje M.A., van Roon, Joel A.G., Ng, Wan-Fai, Bekkering, Siroon, Joosten, Leo A.B., van Helden-Meeuwsen, Cornelia G., van Daele, Paul L.A.; id_orcid   +26 more
core   +2 more sources

β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1

Viruses, 2023
Many studies have shown that β-glucan induces a trained immune phenotype in innate immune cells to defend against bacterial and fungal infections. The specific mechanism involves cellular metabolism and epigenetic reprogramming.
Guolei Wang, Zhiqiang Li, Mingfu Tian, Xianghua Cui, Jun’e Ma, Siyu Liu, Chenglin Ye, Li Yuan, Muhammad Suhaib Qudus, Uzair Afaq, Kailang Wu, Xinghui Liu, Chengliang Zhu   +12 more
doaj   +1 more source

Getting to the Marrow of Trained Immunity [PDF]

Epigenomics, 2018
Contains fulltext : 196392.pdf (Publisher’s version ) (Open Access)
Groh, L.A., Netea, M.G., Netea, M.G., Riksen, N.P., Keating, S.T.   +4 more
openaire   +3 more sources

Circadian rhythm influences induction of trained immunity by BCG vaccination [PDF]

, 2020
BACKGROUND. The antituberculosis vaccine bacillus Calmette-Guérin (BCG) reduces overall infant mortality. Induction of innate immune memory, also termed trained immunity, contributes toward protection against heterologous infections.
Koeken, Valerie ACM, Mourits, Vera P., Barreca, Daniele, Bock, Christoph, Arts, Rob JW, Benn, Christine S., Fife-Gernedl, Victoria, Koeken, Valerie A.C.M., Joosten, Leo AB, Novakovic, Boris, Moorlag, Simone J.C.F.M., Charlotte, L., Moorlag, Simone JCFM, Arts, Rob J.W., van Crevel, Reinout, de Bree, L Charlotte J, Folkman, Lukas, Lemmers, Heidi, Krausgruber, Thomas, Netea, Mihai G., Janssen, Robine, Mourits, Vera P, Joosten, Leo A.B., Dijkstra, Helga, et al.   +24 more
core   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer. [PDF]

Adv Sci (Weinh)
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Liu P, Liu K, Wang K, Guan H, Fan J, Li T, Hao J, Wang Z, Yan Y, Chen J, Ma Y, Yang Y, Niu Y.   +12 more
europepmc   +2 more sources

Lymphocyte crosstalk is required for monocyte-intrinsic trained immunity to Plasmodium falciparum [PDF]

, 2022
Plasmodium falciparum (P. falciparum) induces trained innate immune responses in vitro, where initial stimulation of adherent PBMCs with P. falciparum-infected RBCs (iRBCs) results in hyperresponsiveness to subsequent ligation of TLR2.
Golenbock, Douglas T, Dobbs, Katherine, Dent, Arlene, Crabtree, Juliet N, Kurt-Jones, Evelyn A, de Souza Silva, Leandro, Fitzgerald, Katherine A, Caffrey, Daniel R   +7 more
core   +1 more source

DAMPs and Innate Immune Training [PDF]

Frontiers in Immunology, 2021
The ability to remember a previous encounter with pathogens was long thought to be a key feature of the adaptive immune system enabling the host to mount a faster, more specific and more effective immune response upon the reencounter, reducing the severity of infectious diseases.
Elisa Jentho, Elisa Jentho, Sebastian Weis, Sebastian Weis   +3 more
openaire   +3 more sources

Trained immunity: A Yin‐Yang balance

MedComm, 2022
Traditionally, immune memory is regarded as an exclusive hallmark of adaptive immunity. However, a growing body of evidence suggesting that innate immune cells show adaptive characteristics has challenged this dogma. In the past decade, trained immunity,
Zhidong Hu, Shui‐Hua Lu, Douglas B. Lowrie, Xiao‐Yong Fan   +3 more
doaj   +1 more source