Results 11 to 20 of about 1,089,122 (265)

Trained Immunity and HIV Infection

Frontiers in Immunology, 2022
Findings that certain infections induce immunity not only against the causing agent, but also against an unrelated pathogen have intrigued investigators for many years. Recently, underlying mechanisms of this phenomenon have started to come to light.
Dmitri Sviridov, Dmitri Sviridov, Yury I. Miller, Michael I. Bukrinsky   +3 more
doaj   +4 more sources

‘Trained immunity’: consequences for lymphoid malignancies [PDF]

Haematologica, 2016
In hematological malignancies complex interactions exist between the immune system, microorganisms and malignant cells. On one hand, microorganisms can induce cancer, as illustrated by specific infection-induced lymphoproliferative diseases such as ...
Wendy B.C. Stevens, Mihai G. Netea, Arnon P. Kater, Walter J.F.M. van der Velden   +3 more
doaj   +6 more sources

Trained Immunity as an Adaptive Branch of Innate Immunity [PDF]

International Journal of Molecular Sciences, 2021
The concept of trained immunity has become one of the most interesting and potentially commercially and clinically relevant ideas of current immunology. Trained immunity is realized by the epigenetic reprogramming of non-immunocompetent cells, primarily ...
Vaclav Vetvicka, Petr Sima, Luca Vannucci   +2 more
core   +3 more sources

From trained immunity in allergy to trained immunity-based allergen vaccines. [PDF]

Clinical & Experimental Allergy, 2023
Innate immune cells experience long lasting metabolic and epigenetic changes after an encounter with specific stimuli. This facilitates enhanced immune responses upon secondary exposition to both the same and unrelated pathogens, a process termed trained
Angelina, A., Martín-Cruz, L., Sevilla-Ortega, C., Palomares, O., Subiza, J.L., Domínguez-Andrés, J., Netea, M.G.   +6 more
core   +5 more sources

Immunometabolic circuits in trained immunity [PDF]

Seminars in Immunology, 2016
The classical view that only adaptive immunity can build immunological memory has recently been challenged. Both in organisms lacking adaptive immunity as well as in mammals, the innate immune system can adapt to mount an increased resistance to ...
Joosten, Leo A.B., Arts, R.J., Joosten, L.A., Netea, M.G., Netea, Mihai G., Arts, Rob J.W.   +5 more
core   +5 more sources

Epigenetics and Trained Immunity [PDF]

Antioxidants & Redox Signaling, 2018
SIGNIFICANCE: A growing body of clinical and experimental evidence has challenged the traditional understanding that only the adaptive immune system can mount immunological memory.
Leo A.B. Joosten, Keating, S.T., Marlies P. Noz, Mihai G. Netea, Charlotte D.C.C. van der Heijden, Heijden, C.D.C.C. van der, Joosten, L.A.B., Noz, M.P., Netea, M.G., Niels P. Riksen, Samuel T. Keating, Riksen, N.P.   +11 more
core   +7 more sources

Trained immunity: implications for vaccination [PDF]

Current Opinion in Immunology, 2022
The concept that only adaptive immunity can build immunological memory has been challenged in the past decade. Live attenuated vaccines such as the Bacillus Calmette-Guérin, measles-containing vaccines, and the oral polio vaccine have been shown to ...
Dominguez Andres, J., Föhse, F.K., Geckin, B., Netea, M.G.   +3 more
core   +3 more sources

Therapeutic targeting of trained immunity [PDF]

Nature Reviews Drug Discovery, 2019
Immunotherapy is revolutionizing the treatment of diseases in which dysregulated immune responses have an important role. However, most of the immunotherapy strategies currently being developed engage the adaptive immune system.
Netea, Mihai G, Ochando, Jordi, Mulder, Willem J. M., Mulder, Willem J.M., Joosten, Leo A. B., Joosten, L.A.B., Netea, M.G., Netea, Mihai G., Fayad, Z.A., Joosten, Leo A B, Fayad, Zahi A., Joosten, Leo A.B., Mulder, W.J., Mulder, Willem J M, Fayad, Zahi A, Ochando, J.   +15 more
core   +6 more sources

β-Glucan-Induced Trained Immunity in Dogs

Frontiers in Immunology, 2020
Several observations in the world of comparative immunology in plants, insects, fish and eventually mammals lead to the discovery of trained immunity in the early 2010's. The first demonstrations provided evidence that innate immune cells were capable of
Simon Paris, Simon Paris, Simon Paris, Ludivine Chapat, Marion Pasin, Manon Lambiel, Thomas E. Sharrock, Rishabh Shukla, Cecile Sigoillot-Claude, Jeanne-Marie Bonnet, Hervé Poulet, Ludovic Freyburger, Karelle De Luca   +12 more
doaj   +2 more sources

Mucosal Immunity and Trained Innate Immunity of the Gut

Gastroenterology Insights
Mucosal immunity and trained innate immunity of the gut play a pivotal role in maintaining intestinal homeostasis and defending against microbial pathogens. This review provides an overview of the mechanisms underlying mucosal immunity and the concept of
Tsvetelina Velikova, Issa El Kaouri, Konstantina Bakopoulou, Milena Gulinac, Kremena Naydenova, Martin Dimitrov, Milena Peruhova, Snezhina Lazova   +7 more
doaj   +2 more sources