Results 11 to 20 of about 65,102 (240)
The role of trained immunity in sepsis
Frontiers in ImmunologySepsis is defined as a life-threatening organ dysfunction syndrome caused by dysregulated host response to infection, characterized by a systemic inflammatory response to infection.
Wenjuan Wang +3 more
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Trained Immunity and HIV Infection
Frontiers in Immunology, 2022 Findings that certain infections induce immunity not only against the causing agent, but also against an unrelated pathogen have intrigued investigators for many years. Recently, underlying mechanisms of this phenomenon have started to come to light.
Dmitri Sviridov +3 more
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Trained Immunity Carried by Non-immune Cells [PDF]
Frontiers in Microbiology, 2019 “Trained immunity” is a term proposed by Netea to describe the ability of an organism to develop an exacerbated immunological response to protect against a second infection independent of the adaptative immunity. This immunological memory can last from 1
Attoumani Hamada +3 more
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Maladaptive trained immunity in viral infections [PDF]
The Journal of Clinical InvestigationTrained immunity (TRIM) is a form of long-lasting functional reprogramming of innate immune cells and their progenitors that enhances responsiveness to subsequent stimuli.
Dmitri Sviridov +2 more
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‘Trained immunity’: consequences for lymphoid malignancies [PDF]
Haematologica, 2016 In hematological malignancies complex interactions exist between the immune system, microorganisms and malignant cells. On one hand, microorganisms can induce cancer, as illustrated by specific infection-induced lymphoproliferative diseases such as ...
Wendy B.C. Stevens +3 more
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Trained immunity modulators: A new frontier in immunoregulation and disease intervention [PDF]
Journal of Advanced ResearchBackground: Immunotherapy has emerged as one of the most revolutionary approaches in disease treatments. However, most current and emerging immunotherapeutic strategies primarily target the adaptive immune system.
Jiao Chen +8 more
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Interleukin-38 is a negative regulator of trained immunity—A retrospective multi-omics study [PDF]
iScienceSummary: Trained immunity is a long-lasting innate immune cell phenotype with benefits in infection control and recognized anti-cancer effects. Conversely, inappropriately induced trained immunity contributes to pathological inflammation, warranting the ...
Lisa U. Teufel +12 more
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From trained immunity in allergy to trained
Clinical & Experimental Allergy, 2022 AbstractInnate immune cells experience long lasting metabolic and epigenetic changes after an encounter with specific stimuli. This facilitates enhanced immune responses upon secondary exposition to both the same and unrelated pathogens, a process termed trained immunity.
Leticia Martín‐Cruz +6 more
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Effector-Triggered Trained Immunity: An Innate Immune Memory to Microbial Virulence Factors?
Toxins, 2022 In the last decade, a major dogma in the field of immunology has been called into question by the identification of a cell autonomous innate immune memory.
Cedric Torre, Laurent Boyer
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Trained Immunity as an Adaptive Branch of Innate Immunity [PDF]
International Journal of Molecular Sciences, 2021 The concept of trained immunity has become one of the most interesting and potentially commercially and clinically relevant ideas of current immunology. Trained immunity is realized by the epigenetic reprogramming of non-immunocompetent cells, primarily monocytes/macrophages and natural killer (NK) cells, and is less specific than adaptive immunity ...
Vaclav Vetvicka +2 more
openaire +2 more sources