Results 71 to 80 of about 49,719 (277)

Computer simulations of heterologous immunity: Highlights of an interdisciplinary cooperation [PDF]

Autoimmunity, 2011
The relationship between biological research and mathematical modeling is complex, critical, and vital. In this review, we summarize the results of the collaboration between two laboratories, exploring the interaction between mathematical modeling and wet-lab immunology.
Calcagno, Claudia, Puzone, Roberto, Pearson, Yanthe E., Cheng, Yiming, Ghersi, Dario, Selin, Liisa K., Welsh, Raymond M., Celada, Franco   +7 more
openaire   +3 more sources

Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4+ CD25high T cells with susceptibility in Kenyans

, 2008
Background - Immunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection ...
Magdalena Plebanski, Stephen M. Todryk, Todryk, Stephen M., Plebanski Magdalena, Bejon, P, Hill, Adrian, Tabitha Mwangi, Kevin Marsh, Urban Britta, Flanagan Katie L., Mwangi Tabitha, Plebanski, Magdalena, Urban, B, Britta Urban, Todryk, Stephen, Hill Adrian V. S., Urban, Britta, Katie L Flanagan, Flanagan, KL, Hill, AV, Philip Bejon, Bejon, Philip, Marsh Kevin, Marsh, K, Mwangi, T, Mwangi, Tabitha, Flanagan, Katie, Hill, Adrian V. S., Bejon Philip, Plebanski, M, Katie L. Flanagan, Adrian V S Hill, Todryk Stephen M., Adrian V. S. Hill, Stephen M Todryk, Marsh, Kevin, Todryk, SM, Flanagan, Katie L.   +37 more
core   +1 more source

NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice

Advanced Science, EarlyView.
In rice, NLSS3 binds and shields SHM1 from autophagic degradation to maintain serine homeostasis. The A132P mutation in nlss3 disrupts this, triggering SHM1 loss, metabolic dysfunction, K+ imbalance, and impaired ROS scavenging, which collectively drive narrow leaves and salt sensitivity.
Xiong Liu, Yulu Yang, Zhiqi Hao, Jing Xu, Huibo Zhao, Qiang Zhang, Deyong Ren, Xia Li, Guojun Dong, Lan Shen, Li Zhu, Jiang Hu, Zhenyu Gao, Qing Li, Qian Qian, Guangheng Zhang   +15 more
wiley   +1 more source

The two faces of heterologous immunity: protection or immunopathology

Journal of Leukocyte Biology, 2013
ABSTRACTImmunity to previously encountered viruses can alter responses to unrelated pathogens. This phenomenon, which is known as heterologous immunity, has been well established in animal model systems. Heterologous immunity appears to be relatively common and may be beneficial by boosting protective responses.
Shalini, Sharma, Paul G, Thomas
openaire   +3 more sources

BCG vaccination: a role for vitamin D? [PDF]

, 2011
BCG vaccination is administered in infancy in most countries with the aim of providing protection against tuberculosis. There is increasing interest in the role of vitamin D in immunity to tuberculosis.
Hazel M. Dockrell, Rose Blitz, Branson Keith, Maeve K. Lalor, Blitz, R, Lalor Maeve K., Fine Paul E., Branson, K, Hazel M Dockrell, Maeve K Lalor, Floyd Sian, Fine, PE, Rosemary E Weir, Weir, RE, Gorak-Stolinska, Patricia, Rosemary E. Weir, Sian Floyd, Fine, Paul E, Lalor, MK, Floyd, Sian, Paul E. Fine, Blitz, Rose, Dockrell Hazel M., Weir, Rosemary E, Keith Branson, Paul E Fine, Weir Rosemary E., Gorak-Stolinska, P, Dockrell, HM, Gorak-Stolinska Patricia, Lalor, Maeve K, Dockrell, Hazel M, Branson, Keith, Patricia Gorak-Stolinska, Floyd, S, Blitz Rose   +35 more
core   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Suppression of heterologous immunity by Nematospiroides dubius antigens in vitro [PDF]

International Journal for Parasitology, 1989
The direct effect of the soluble antigens in the homogenate of adult Nematospiroides dubius (AH) on spleen cells from uninfected NIH mice was investigated using a Mishell-Dutton culture system. Parasite antigens were shown to reduce the plaque-forming cell (PFC) response to sheep red blood cells (SRBC) in a dose-dependent manner in vitro.
Crawford, C.R., Behnke, Jerzy M., Pritchard, D.I.   +2 more
openaire   +3 more sources

Mouse Models of Heterologous Flavivirus Immunity: A Role for Cross-Reactive T Cells [PDF]

, 2019
Most of the world is at risk of being infected with a flavivirus such as dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, tick-borne encephalitis virus, and Zika virus, significantly impacting millions of lives. Importantly,
James D. Brien, Amelia K. Pinto, Mariah Hassert   +2 more
core   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Heterologous prime-boost vaccination with VLA2001 and an ORFV-based vector enhances spike- and nucleocapsid-specific immunity in mice

Frontiers in Immunology
Heterologous prime–boost vaccination has emerged as a promising approach to enhance immune responses by combining vaccines with complementary mechanisms of antigen delivery and immune activation.
Alena Reguzova, Verena Haug, Verena Haug, Carina Metz, Carina Metz, Melanie Müller, Madeleine Fandrich, Alex Dulovic, Ralf Amann   +8 more
doaj   +1 more source