Results 81 to 90 of about 49,719 (277)

Perforin and Gamma Interferon Expression Are Required for CD4(+) and CD8(+) T-Cell-Dependent Protective Immunity against a Human Parasite, Trypanosoma cruzi, Elicited by Heterologous Plasmid DNA Prime-Recombinant Adenovirus 5 Boost Vaccination

, 2009
A heterologous prime-boost strategy using plasmid DNA, followed by replication-defective recombinant adenovirus 5, is being proposed as a powerful way to elicit CD4(+) and CD8(+) T-cell-mediated protective immunity against intracellular pathogens.
Machado, Alexandre V., Filipe A. Haolla, Rodrigues, Mauricio M., Bruna C. G. de Alencar, Gazzinelli, Ricardo T., Persechini, Pedro M., Silverio, Jaline C., Lannes-Vieira, Joseli, Oscar Bruna-Romero, Mauricio M. Rodrigues, Bruna-Romero, Oscar, Haolla, Filipe A., Rodrigues, Mauricio M. [UNIFESP], Joseli Lannes-Vieira, Haolla, Filipe A. [UNIFESP], Ricardo T. Gazzinelli, Gabriel de Oliveira, Oliveira, Gabriel de, Alencar, Bruna C. G. de, Jaline C. Silverio, Alencar, Bruna C. G. de [UNIFESP], Alexandre V. Machado, Pedro M. Persechini   +22 more
core   +1 more source

A novel mouse model of endometriosis: Simulating the recurrent hemorrhagic microenvironment of clinical lesions

Animal Models and Experimental Medicine, EarlyView.
To address the limitations of existing models, this study innovatively established a mouse model of endometriosis (EMs) capable of mimicking cyclic bleeding. Our results confirmed that this model recapitulates the complete pathological progression from ectopic lesion establishment to systemic responses, exhibiting superior clinical relevance compared ...
Yu Zhuang, Yan Zan, Tiantian Ma, Xiaoquan Huang, Junwei Li, Liangjun Xia, Yuping Sa, Youbing Xia   +7 more
wiley   +1 more source

Intranasal Liposomal Formulation of Spike Protein Adjuvanted with CpG Protects and Boosts Heterologous Immunity of hACE2 Transgenic Mice to SARS-CoV-2 Infection [PDF]

Vaccines (Basel), 2023
Russo M, Mendes-Corrêa MC, Lins BB, Kersten V, Pernambuco Filho PCA, Martins TR, Tozetto-Mendoza TR, Vilas Boas LS, Gomes BM, Dati L, Duarte-Neto AN, Reigado GR, Frederico ABT, De Brito e Cunha DRdA, De Paula AV, Da Silva JG, Vasconcelos CM, Chambergo FS, Nunes VA, Ano Bom APD, Castilho LR, Martins RT, Hirata MH, Mirotti L.   +23 more
europepmc   +2 more sources

T and B cell responses in different immunization scenarios for COVID-19: a narrative review

Frontiers in Immunology
Vaccines against COVID-19 have high efficacy and low rates of adverse events. However, none of the available vaccines provide sterilizing immunity, and reinfections remain possible.
Eva Piano Mortari, Francesca Ferrucci, Irini Zografaki, Rita Carsetti, Luciano Pacelli   +4 more
doaj   +1 more source

Induction and in Vitro demonstration of cellular immunity to DNA and RNA viruses in guinea-pigs [PDF]

, 1975
Guinea-pigs were immunized with different cells infected with vaccinia virus, herpes simplex virus type 1, herpesvirus saimiri, and the virus of vesicular stomatitis. Development of cellular immunity against these viruses was observed with transformation
U. Koszinowski, Koszinowski, Ulrich H., G. Bandlow, Bandlow, G.   +3 more
core  

Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection

Animal Models and Experimental Medicine, EarlyView.
A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang, Shicheng Wan, Yanmin Guo, Hongyu Han, Fei Luo, Dongmei Jiang, Xiaorong Yang, Quanhai Pang, Haisheng Yu, Jinlian Hua   +9 more
wiley   +1 more source

Studies on heterologous immunity in schistosomiasis. 4. Heterologous schistosome immunity in cattle.

Bulletin of the World Health Organization, 1970
Previous studies have shown that when mice and monkeys are infected with bovine schistosomes they develop a considerable degree of heterologous immunity against subsequent challenge with Schistosoma mansoni. The present report describes a study on the reverse effect in which calves were first exposed to cercariae of S.
M F, Hussein, A A, Saeed, G S, Nelson
openaire   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Demonstration of cross-protective vaccine immunity against an emerging pathogenic Ebolavirus Species. [PDF]

PLoS Pathogens, 2010
A major challenge in developing vaccines for emerging pathogens is their continued evolution and ability to escape human immunity. Therefore, an important goal of vaccine research is to advance vaccine candidates with sufficient breadth to respond to new
Lisa E Hensley, Sabue Mulangu, Clement Asiedu, Joshua Johnson, Anna N Honko, Daphne Stanley, Giulia Fabozzi, Stuart T Nichol, Thomas G Ksiazek, Pierre E Rollin, Victoria Wahl-Jensen, Michael Bailey, Peter B Jahrling, Mario Roederer, Richard A Koup, Nancy J Sullivan   +15 more
doaj   +1 more source

Studies on heterologous immunity in schistosomiasis. I. Heterologous schistosome immunity in mice.

Bulletin of the World Health Organization, 1968
Epidemiological and experimental studies indicate that heterologous immunity resulting from exposure to bovine and other animal schistosomes might be of some importance in determining the relative severity of schistosome infection in man in different parts of the world.
G S, Nelson, M A, Amin, M F, Saoud, C, Teesdale   +3 more
openaire   +1 more source