Results 91 to 100 of about 49,719 (277)

Immunogenicity of heterologous recombinant adenovirus prime-boost vaccine regimens is enhanced by circumventing vector cross-reactivity

, 2006
The high prevalence of preexisting immunity to adenovirus serotype 5 (Ad5) in human populations has led to the development of recombinant adenovirus (rAd) vectors derived from rare Ad serotypes as vaccine candidates for human immunodeficiency virus type ...
Thorner, Anna R., Lynch, Diana M., Denholtz, Matthew, Havenga, Menzo J. E., Lemckert, Angelique A. C., Goudsmit, Jaap, Barouch, Dan H., Ewald, Bonnie A.   +7 more
core   +1 more source

Prediction of Human Serum Concentration–Time Profiles of Golimumab and Ustekinumab Using Pharmacokinetic Data From Common Marmosets With Assessment of Anti‐Drug Antibodies

Biopharmaceutics &Drug Disposition, EarlyView.
This study identified new optimal allometric scaling exponents for human PK prediction of monoclonal antibodies with linear PKs from marmoset PK data. In addition, immunogenicity in common marmosets was evaluated following the repeated dose of golimumab and ustekinumab, minimal anti‐drug antibodies were detected.
Ayaka Tajiri, Shogo Matsumoto, Nanami Furukawa, Kensuke Kagiyama, Hiroshi Ikeda, Kazumasa Fukasawa, Hiroki Takano   +6 more
wiley   +1 more source

Studies on heterologous immunity in schistosomiasis. 5. Heterologous schistosome immunity in sheep.

Bulletin of the World Health Organization, 1973
Previous studies have shown that when cattle are exposed to cercariae of Schistosoma mansoni they develop considerable resistance to subsequent challenge with S. mattheei. The present study showed that when sheep are immunized with S. mansoni cercariae they too develop a marked resistance to subsequent challenge with S. mattheei.
J M, Preston, G S, Nelson, A A, Saeed
openaire   +1 more source

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Sterile protection against P. vivax malaria by repeated blood stage infection in the Aotus monkey model

Life Science Alliance
Repeated blood stage infections with the human malaria parasite, Plasmodium vivax , induce sterile strain-specific and partial strain-transcendent protection in the Aotus monkey model.
Nicanor Obaldía, Joao Luiz Da Silva Filho, Marlon Núñez, Katherine A Glass, Tate Oulton, Fiona Achcar, Grennady Wirjanata, Manoj Duraisingh, Philip Felgner, Kevin KA Tetteh, Zbynek Bozdech, Thomas D Otto, Matthias Marti   +12 more
doaj   +1 more source

Studies on heterologous immunity in schistosomiasis. 3. Further observations on heterologous immunity in mice.

Bulletin of the World Health Organization, 1970
Previous studies on heterologous immunity in mice and rhesus monkeys have shown that immunization with Schistosoma bovis, S. mattheei or S. rodhaini cercariae can limit the severity of infection resulting from subsequent challenge with S. mansoni. The present report describes further evidence of the protection afforded by heterologous immunization.
M A, Amin, G S, Nelson
openaire   +1 more source

Characterization and immunogenicity of nanoparticle vaccines displaying embecovirus spike proteins

Biotechnology Progress, EarlyView.
Virus‐like particle vaccines displaying spike proteins from OC43, HKU1 A, and HKU1 B were evaluated in mice for their ability to elicit antibodies against the spike proteins from OC43, HKU1 A, HKU1 B, and HKU1 C. Abstract Endemic human coronaviruses OC43 and HKU1 cause widespread respiratory infections and can be associated with severe illness in ...
Peter J. Halfmann, Augustine Duffy, Alex Wee, Noah Anderson, Jackson Terrell, Yoshihiro Kawaoka, Ravi S. Kane   +6 more
wiley   +1 more source

Management of severe bone loss in patients at risk of medication‐related osteonecrosis of the jaw with microsurgery and guided bone regeneration: A case study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Medication‐related osteonecrosis of the jaw (MRONJ) is a challenging complication associated with antiresorptive medications. Its exact pathophysiology remains unclear, but dental extractions and infections are known triggers, complicating prevention, and treatment.
Pedro Franco Ferreira, José Maurício Paradella de Camargo, Lara Maria Alencar Ramos Innocentini, Ana Carolina Fragoso Motta   +3 more
wiley   +1 more source