Results 91 to 100 of about 1,396,897 (310)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Are suicide rates related to the psychiatrist density? A cross-national study.
Frontiers in Public Health, 2016 Introduction. Most suicide victims have a diagnosable psychiatric disorder. Treatment of psychiatric disorders should reduce the number of suicides. Higher psychiatrist-per-population ratio increases the opportunity for contact between the patient and ...
Leo eSher
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Tobacco Quit Rates among Youth in an Urban Health Centre of Mumbai: A Cross Sectional Study [PDF]
Addiction and Health, 2011 Background: Tobacco use is a major cause of preventable death and disease in India. A nationally representative case-control study of smoking in India (2008) revealed that only 2% of smokers had spontaneously quit.
Saurabh Ram BihariLal Shrivastava +1 more
doaj
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
What does a G-3 target zone mean for emerging-market economies? [PDF]
This paper examines the argument for a G-3 exchange rate target zone strictly from an emerging market perspective. A commitment to damping G-3 exchange rate fluctuations, however, requires a willingness on the part of G-3 authorities to use domestic ...
Reinhart, Carmen, Reinhart, Vincent
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Pakistan Armed Forces Medical Journal, 2020 Objective: To determine the rates of HCV seroconversion in patients undergoing hemodialysis (HD) in dialysis units of tertiary care hospitals. Study Design: Descriptive cross-sectional study.
Muhammad Asif +5 more
doaj +2 more sources