Results 71 to 80 of about 361,487 (286)

Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine. [PDF]

, 2019
Histamine (HA) is an important food contaminant generated during food fermentation or spoilage. However, an immunoassay for direct (derivatization free) determination of HA has rarely been reported due to its small size to induce the desired antibodies ...
Dong, Jie-Xian, Hammock, Bruce, Jia, Bao-Zhu, Lei, Hong-Tao, Luo, Lin, Shen, Yu-Dong, Wang, Hong, Wei, Xiao-Qun, Xu, Zhen-Lin, Yang, Jin-Yi   +9 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Case of Cross-Reactivity

Chemistry & Biology, 2011
Studies using chemical inhibitors have suggested that p38 MAP kinase is a key regulator of Wnt/β-catenin signaling. In this issue, Verkaar et al. (2011) show that cross-reactivity of p38 inhibitors with casein kinase Iδ/ɛ is responsible for Wnt/β-catenin pathway inhibition.
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Shigella sonnei and Shigella flexneri: Epidemiology supporting development of cross-protective vaccines

Human Vaccines & Immunotherapeutics
Shigellosis represents a major global health challenge, significantly contributing to mortality among children under five, particularly in sub-Saharan Africa and South Asia. Advances in molecular techniques have underscored the extensive global impact of
Valentina Caradonna, Agnes Hunyady, Usman Nakakana, Miren Iturriza, Francesca Micoli, Omar Rossi, Francesca Mancini   +6 more
doaj   +1 more source

Identification of candidate antigens from adult stages of Toxocara canis for the serodiagnosis of human toxocariasis

Memorias do Instituto Oswaldo Cruz, 2011
In the present work, we identified adult Toxocara canis antigens through sodium dodecyl sulfate-polyacrylamide gel electrophoresis for potential use in human toxocariasis immunodiagnosis. The sensitivity and specificity of several semi-purified antigens,
Patrícia Longuinhos Peixoto, Evaldo Nascimento, Guilherme Grossi Lopes Cançado, Rodrigo Rodrigues Cambraia de Miranda, Regina Lunardi Rocha, Ricardo Nascimento Araújo, Ricardo Toshio Fujiwara   +6 more
doaj   +1 more source

A Novel Sensitive Immunoassay Targeting the 5-Methylthio-d-Xylofuranose-Lipoarabinomannan Epitope Meets the WHO's Performance Target for Tuberculosis Diagnosis. [PDF]

, 2018
The only currently commercialized point-of-care assay for tuberculosis (TB) that measures lipoarabinomannan (LAM) in urine (Alere LF-LAM) has insufficient sensitivity.
Broger, Tobias, Choudhary, Alok, Denkinger, Claudia M, Honnen, William J, Katsuragi, Kiyonori, Kawasaki, Masanori, Li, Andra, Lowary, Todd L, Mathew, Anu, Nahid, Payam, Pinter, Abraham, Plisova, Tatiana, Shen, Ke, Sigal, George B, Tsionsky, Michael, Zheng, Ruixiang Blake   +15 more
core  

Kinetic Characterisation of a Single Chain Antibody against the Hormone Abscisic Acid: Comparison with Its Parental Monoclonal [PDF]

, 2016
A single-chain Fv fragment antibody (scFv) specific for the plant hormone abscisic acid (ABA) has been expressed in the bacterium Escherichia coli as a fusion protein.
A Hayhurst, A Sadanandom, A Wörn, AM Jones, Andrew J. Thompson, Andrew Marsh, B Kazemier, D Missiakas, DG Myszka, DG Myszka, DM Hoover, Ellen R Goldman, George O. Badescu, GM Banowetz, J Messens, J Phillips, J Wigger, LLH Christensen, M Malmqvist, MK Walker-Simmons, O Artsaenko, O Artsaenko, P Jurado, P Martineau, PB Luppa, Q Li, R Mertens, R Raag, R Waadt, Richard M. Napier, S Shaki-Loewensteina, SA Quarrie, SA Quarrie, SM Kipriyanova, Timothy R. Smith, TR Smith, UL Jönsson, WFM Stöcklein, Y-W Li   +38 more
core   +5 more sources

Flavivirus-induced antibody cross-reactivity

Journal of General Virology, 2011
Dengue viruses (DENV) cause countless human deaths each year, whilst West Nile virus (WNV) has re-emerged as an important human pathogen. There are currently no WNV or DENV vaccines licensed for human use, yet vaccines exist against other flaviviruses.
Mansfield, KL, Horton, DL, Johnson, N, Li, L, Barrett, ADT, Smith, DJ, Galbraith, SE, Solomon, T, Fooks, AR   +8 more
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source