Results 101 to 110 of about 918,156 (339)

Aneuploidy underlies brefeldin A-induced antifungal drug resistance in Cryptococcus neoformans

Frontiers in Cellular and Infection Microbiology
Cryptococcus neoformans is at the top of the list of “most wanted” human pathogens. Only three classes of antifungal drugs are available for the treatment of cryptococcosis.
Zhi-hui Zhang, Liu-liu Sun, Bu-qing Fu, Jie Deng, Cheng-lin Jia, Ming-xing Miao, Feng Yang, Feng Yang, Yong-bing Cao, Tian-hua Yan   +9 more
doaj   +1 more source

389P Lack of cross-resistance to erlotinib in human head and neck cancer cells with acquired resistance to cetuximab [PDF]

, 2023
James A. Bonner, Chuan Xing, Hoa Q. Trummell   +2 more
openalex   +1 more source

Synergistic effect of the homologous PB1–NA gene constellation in Influenza A virus reassortants: Evaluation and characterization of reassortant influenza variant viruses cross-resistant to influenza Neuraminidase Inhibitors [PDF]

, 2016
This project aims to elucidate the functional impact of specific mutation induced changes in the NA and PB1 genes on the viral fitness and cross-resistance profile of A(H1N1)pdm09 viruses.info:eu-repo/semantics ...
Louro, João, Rebelo-de-Andrade, Helena
core  

Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells [PDF]

, 2006
Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant cancers but there is little known ...
A Ibrahim, A Rennicke, AB Sandler, AP Jekunen, BA Jansen, BA Teicher, Britta K. Stordal, BS Burns, C Kollmannsberger, C Kollmannsberger, CR Culy, D Pectasides, D Pectasides, DC Marks, G Belvedere, G Lenz, G Tisman, GA Hospers, H Kawai, H Kuroda, HD Preisler, HD Preisler, IS Song, J Liu, JM Woynarowski, JM Woynarowski, K Suzukake, K Yamamoto, KV Grech, L Pendyala, L Poulain, M Abal, M Markman, M Mishima, Mary W. Davey, N Jain, N Savaraj, N Thatcher, O Rixe, P Chollet, P Soulie, PJ Kuppen, PR Twentyman, R Sockalingam, RD Christen, Ross A. Davey, S Hector, S Ohta, SG Chaney, SL Lai, SW Johnson, T Fojo, T Moritaka, T Tashiro, V Dieras, VL Locke, WS Hong, Z El Akawi, Z Wang   +58 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Detection of KPC-216, a Novel KPC-3 Variant, in a Clinical Isolate of Klebsiella pneumoniae ST101 Co-Resistant to Ceftazidime-Avibactam and Cefiderocol

Antibiotics
Background: Carbapenemase-producing Klebsiella pneumoniae (CP-KP) represents a global threat to public health, with limited antimicrobial therapeutic options. In this study, we analyzed a ceftazidime/avibactam (CAZ-AVI)-resistant K.
Maria Giufrè, Giulia Errico, Maria Del Grosso, Michela Pagnotta, Bernardetta Palazzotti, Milva Ballardini, Annalisa Pantosti, Marcello Meledandri, Monica Monaco   +8 more
doaj   +1 more source

Glyphosate resistance in annual ryegrass (Lolium rigidum Gaud.) with multiple resistance mechanisms. [PDF]

, 2010
Glyphosate (N-(phosphonomethyl)glycine) is a post-emergent, systemic and non-selective herbicide for the control of annual and perennial weeds. This herbicide has very low toxicity to the mammals.
Bostamam, Yazid
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Editorial: Multiple Herbicide-Resistant Weeds and Non-target Site Resistance Mechanisms: A Global Challenge for Food Production

Frontiers in Plant Science, 2021
Joel Torra, María Dolores Osuna, Aldo Merotto, Martin Vila-Aiub   +3 more
doaj   +1 more source

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]

, 2008
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi, Borgnetto, Brown, Cambau, Champoux, Corbett, Corbett, Ferrero, Fisher, Gatto, Higgins, Kawada, L. M. Fisher, M. Dias, M. Palumbo, Marians, Maxam, McCullough, Mizuuchi, Morrison, Pan, Pan, Pan, Pan, Pan, Peden, Pozzi, Richter, Richter, Richter, Shea, X. S. Pan, Yague, Yoshida, Zechiedrich   +34 more
core   +1 more source