Results 131 to 140 of about 6,863,210 (309)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A bomb from Australia [picture] /

, 1917
Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Inscription: "Stan Cross Feb 18th 1917"--In ink, lower left. "A Bomb From Australia"--In ink, upper margin; "Stan Cross 94 Aberdeen St Perth"--In pencil, on verso.; Also available in an
Cross, Stan, 1888-1977.
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Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Wally and the Major, tenth edition [picture] /

, 1940
Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Inscription: "Wally and the Major, Tenth edition, By Stan Cross, 1/-"--In ink. "Stan Cross"--In pencil, lower right; "page 6"--In pencil, on note attached to verso.; Also available in ...
Cross, Stan, 1888-1977.
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Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

First aid [picture] /

, 1910
Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Inscription: "Stan Cross"--in ink, lower right. "Stan Cross"--in ink, lower right.
Cross, Stan, 1888-1977.
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

In confidence [picture] /

, 1930
Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Inscription: "Stan Cross"--In ink, lower right. "In confidence"--In pencil, lower margin; "Stan Cross F. U.
Cross, Stan, 1888-1977.
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Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Design plans, reduction number one, forrard gantry view from aft [picture] : "davit end and raftside" "davit end top view" "forrard gantry view from aft" "forrard gantry side view" /

, 1900
Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; "Stan Cross"--In ink, lower right. "Reduction No. 1 on 4418 sh[?]"--In pencil, upper left; "sheet 4"--In ink, upper right corner; "Stan Cross 39 Wallaroy Rd Woollahra"--In ink, lower ...
Cross, Stan, 1888-1977.
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