Results 111 to 120 of about 9,602,604 (312)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

T2K on-axis detector results: cross section measurements

EPJ Web of Conferences, 2015
The T2K experiment brings the world leading constraints on the atmospheric parameters, sin2θ23 = 0.514 ± 0.082 and |Δm322| = (2.44−0.15+0.17) × 10−3eV2.c−4, along with first observation of the electron neutrino appearance in the muon neutrino beam.
Quilain Benjamin
doaj   +2 more sources

Partial photoneutron cross section measurements on 209Bi

EPJ Web of Conferences, 2017
New data of total and partial (γ,xn) cross sections with x = 1–3 are proposed to be measured by direct neutron multiplicity sorting using Laser Compton scattering (LCS) gamma ray beams at the ELI-NP to solve long standing discrepancies between existing ...
Gheorghe Ioana, Filipescu Dan, Katayama Seitaro, Utsunomiya Hiroaki, Belyshev Sergey, Stopani Konstantin, Varlamov Vladimir, Shima Tatsushi, Lui Yiu-Wing, Amano Sho, Miyamoto Shuji   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Higgs plus jet production in bottom quark annihilation at next-to-leading order

, 2010
The cross section for Higgs+jet production in bottom quark annihilation is calculated through NLO QCD. The five-flavour scheme is used to derive this contribution to the Higgs+jet production cross section which becomes numerically important in the MSSM ...
Aaltonen, Amsler, Barnett, Belyaev, Belyaev, Belyaev, Boos, Bozzi, Bozzi, Brein, Brein, Brein, Campbell, Catani, Catani, Catani, Dawson, de Florian, de Florian, Degrassi, Dicus, Dicus, Dittmaier, Dittmaier, Djouadi, Djouadi, Ellis, Englert, Field, Glashow, Glosser, Guralnik, Harlander, Harlander, Harlander, Higgs, Kemal J. Ozeren, Kulesza, Maltoni, Marius Wiesemann, Martin, Martin, Nagy, Nagy, Nagy, Nilles, Plehn, Rainwater, Ravindran, Robert V. Harlander, Salam, Tevatron New Phenomena & Higgs Working Group, Weinberg   +52 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

High temperature thermocouple design provides gas cooling without increasing overall size of unit [PDF]

, 1967
High temperature thermocouple uses a thermoelement of noncircular cross section with insulation of circular cross section to provide space for the flow of coolant gas down the ...
Zellner, G. J.
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source