Results 111 to 120 of about 2,803,084 (343)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

Differential Mortality and Wealth Accumulation [PDF]

open access: yes
The issue of asset accumulation and decumulation is central to the life cycle theory of consumer behavior and to many policy questions. One of the main implications of the life cycle model is that assets are decumulated in the last part of life.
Hilary W. Hoynes, Orazio P. Attanasio
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Junk food consumption among undergraduate medical students in a medical college at Kolkata: A cross-sectional study

open access: yesJournal of Clinical and Scientific Research
Background: Junk food consumption is a common phenomenon amongst youths, including medical students, with its several health hazards. The objective of this study was to assess the junk food consumption pattern amongst medical students and to identify ...
Supantha Chatterjee   +4 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Anemia em escolares da primeira série do ensino fundamental da rede pública de Maceió, Alagoas, Brasil

open access: yesCadernos de Saúde Pública
Realizou-se um estudo transversal com amostra probabilística de 426 alunos de 6 a 10 anos, da 1ª série do ensino fundamental das escolas públicas de Maceió, Alagoas, Brasil. O objetivo foi avaliar a prevalência da anemia e sua associação com o retardo de
Célia Dias dos Santos   +4 more
doaj  

Assessing the Elderly Health-related Unmet Needs and Some Related Factors in Hamadan City, Iran [PDF]

open access: yesSālmand
Objectives The increase in the older adult population is a public health challenge worldwide. The present study is designed and conducted as a cross-sectional study to identify the specific types of needs among the elderly population. Methods & Materials
Fatemeh Mansouri-Shad   +4 more
doaj  

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