Results 91 to 100 of about 1,589,263 (300)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Outliers in Cross-Sectional Regression [PDF]

The robustness of the results coming from an econometric application depends to a great extent on the quality of the sampling information. This statement is a general rule that becomes especially relevant in a spatial context where data usually have lots
Jørgen Lauridsen, Jesus Mur
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The relation between time-series and cross-sectional effects of idiosyncratic variance on stock returns in G7 countries [PDF]

This paper suggests that CAPM-based idiosyncratic variance (IV) correlates negatively with future stock returns because it is a proxy for loadings on discount-rate shocks in Campbell*s (1993) ICAPM.
Hui Guo, Robert Savickas
core  

Intertemporal choice and the cross-sectional variance of marginal utility [PDF]

, 2001
The theory of intertemporal choice predicts that the cross-sectional variance of the marginal utility of consumption is equal to its own lag plus a constant and a random component.
Orazio P. Attanasio, Attanasio, O., ATTANASIO O, Tullio Jappelli, JAPPELLI, Tullio, Jappelli, T., Orazio P. Attanasio, ATTANASIO, O   +7 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Estimating health expectancies from two cross-sectional surveys [PDF]

Health expectancies are key indicators for monitoring the health of populations, as well as for informing debates about compression or expansion of morbidity. However, current methodologies for estimating them are not entirely satisfactory.
Michel Guillot, Yan Yu
core  

Cross-sectional studies* (n = 16)–Direction and significance of the relationship between reward processing and self-regulation.

Cross-sectional studies* (n = 16)–Direction and significance of the relationship between reward processing and self-regulation.
Efstathios Papachristou (445512), Eirini Flouri (8834063), Francesca Bentivegna (18309940)   +2 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Protocol for the development of a reporting guideline for umbrella reviews on epidemiological associations using cross-sectional, case-control and cohort studies: the Preferred Reporting Items for Umbrella Reviews of Cross-sectional, Case-control and Cohort studies (PRIUR-CCC). [PDF]

INTRODUCTION Observational studies are fraught with several biases including reverse causation and residual confounding. Overview of reviews of observational studies (ie, umbrella reviews) synthesise systematic reviews with or without meta-analyses of
Kelly Cobey, Moher, David,, Papatheodorou, Stefania,, Cortese, Samuele, Egger, Matthias, Solmi, Marco,, Beverley Shea, Marco Solmi, Shin, Jae Il, Ioannidis, John P., Nicola Veronese, Carvalho, Andre F.,, Dragioti, Elena,, Shea, Beverley, Jae Il Shin, Shin, Jae Il,, Radua, Joaquim, Radua, Joaquim,, Hartling, Lisa, Moher, David, Pollock, Michelle,, Ebrahimzadeh, Sanam, Carvalho, Andre F, Cobey, Kelly,, Stefania Papatheodorou, Ioannidis, John P, Michelle Pollock, Lisa Hartling, Egger, Matthias,, Joaquim Radua, Carvalho, Andre F., Cortese, Samuele,, Shea, Beverley,, Cobey, Kelly, Pollock, Michelle, Sanam Ebrahimzadeh, Dragioti, Elena, Ebrahimzadeh, Sanam,, Veronese, Nicola, Papatheodorou, Stefania, Andre F Carvalho, Samuele Cortese, Elena Dragioti, Ioannidis, John P.,, Hartling, Lisa,, Solmi, Marco, John P Ioannidis, Veronese, Nicola,   +47 more
core   +1 more source