Results 71 to 80 of about 1,270,321 (253)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Anemia em escolares da primeira série do ensino fundamental da rede pública de Maceió, Alagoas, Brasil

Cadernos de Saúde Pública
Realizou-se um estudo transversal com amostra probabilística de 426 alunos de 6 a 10 anos, da 1ª série do ensino fundamental das escolas públicas de Maceió, Alagoas, Brasil. O objetivo foi avaliar a prevalência da anemia e sua associação com o retardo de
Célia Dias dos Santos, Leonor Maria Pacheco Santos, José Natal Figueiroa, Pajuçara Maria Guimarães Marroquim, Maria Alice Araújo Oliveira   +4 more
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Uso de métodos anticoncepcionais e adequação de contraceptivos hormonais orais na cidade de Pelotas, Rio Grande do Sul, Brasil: 1992 e 1999

Cadernos de Saúde Pública
Realizou-se um estudo transversal de base populacional, com o objetivo de verificar a utilização de métodos contraceptivos e adequação do emprego de anticoncepcionais orais pelas mulheres de 20 a 49 anos, residentes na zona urbana da cidade de Pelotas ...
Juvenal Soares Dias-da-Costa, Denise Petrucci Gigante, Ana Maria Baptista Menezes, Maria Teresa Anselmo Olinto, Silvia Macedo, Marcelo Alexandre Pinto de Britto, Sandra Costa Fuchs   +6 more
doaj  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Algumas considerações metodológicas sobre os estudos epidemiológicos das Lesões por Esforços Repetitivos (LER)

Cadernos de Saúde Pública
As lesões por esforços repetitivos (LER) constituem-se um problema de saúde pública, com repercussões sociais e econômicas. Este artigo apresenta uma revisão crítica dos estudos epidemiológicos das últimas duas décadas.
Serafim Barbosa Santos Filho, Sandhi Maria Barreto   +1 more
doaj  

Comfortable Walking Speed After Chronic Stroke is Governed by Step/Stride- Length of Mechanics With Independent Effects Balance Capacity

Physical Therapy Korea
Background: Comfortable gait speed after stroke is key to community ambulation, but the roles of step/stride-length mechanics, balance capacity, and balance confidence remain uncertain.
Hyun-min Moon
doaj   +1 more source

Junk food consumption among undergraduate medical students in a medical college at Kolkata: A cross-sectional study

Journal of Clinical and Scientific Research
Background: Junk food consumption is a common phenomenon amongst youths, including medical students, with its several health hazards. The objective of this study was to assess the junk food consumption pattern amongst medical students and to identify ...
Supantha Chatterjee, Sukesh Das, Avijit Das, Sajib Chakraborty, Tarun Kumar Sarkar   +4 more
doaj   +1 more source