Results 51 to 60 of about 1,589,263 (300)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Cross-sectional cohort comparisons summary (secondary meta-analysis).

, 2023
(1) Overview of participant demographics and injury characteristics for the pooled cohort comparisons. (2) Summary of the individual studies included in the review.
Carole Lunny (769209), Daniel D. Hodgkiss (17458593), Andrei V. Krassioukov (5704454), Shin-Yi Chiou (448775), Matthias Walter (820008), Tom E. Nightingale (4495174), Samuel J. E. Lucas (10584224), Gurjeet S. Bhangu (17458596), Catherine R. Jutzeler (8280150)   +8 more
core   +1 more source

Psychiatric Morbidities of Elderly Out-patients Attending Various Outreach Clinics in Gandaki Province of Nepal: A Descriptive Cross-sectional Study

Journal of Nepal Medical Association, 2020
Introduction: Dramatic growth of the aging population resulted in an increased number of mental disorders and such data are limited in Nepal. The objective is to find out the psychiatric morbidities of elderly out-patients attending Baglung, Kusma ...
Jai Bahadur Khattri, Srijana Thapa Godar, Anil Subedi, Shweta Tirkey   +3 more
doaj   +1 more source

Descripción basal de la cohorte nacional prospectiva de hemangiomas infantiles de la Academia Española de Dermatología y Venereología. Comparación de los pacientes tratados con propranolol en la práctica clínica rutinaria y los datos del ensayo clínico pivotal previo

Actas Dermo-Sifiliográficas, 2021
Resumen: Introducción: Existen diversas opciones terapéuticas para los hemangiomas infantiles (HI). El propranolol se utiliza con base en un ensayo pivotal. Nuestro objetivo fue describir las características del HI en la práctica clínica, incluyendo las
C. Cuenca-Barrales, E. Baselga-Torres, J. del Boz-González, A. Vicente, S.I. Palencia-Pérez, M. Campos-Domínguez, M. Valdivieso-Ramos, A. Martín-Santiago, M.T. Monserrat-García, A. Azón-Masoliver, M. Feito-Rodríguez, J.J. Domínguez-Cruz, E. Roé-Crespo, C. Salas-Márquez, A. Giacaman, A.I. Lorente-Lavirgen, L. Quintana-Castanedo, M. de Vega-Martínez, I. García-Doval, J. Bernabéu-Wittel   +19 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Bone cross-sectional geometry in male runners, gymnasts, swimmers and non-athletic controls: a hip-structural analysis study.

, 2011
Loading of the skeleton is important for the development of a functionally and mechanically appropriate bone structure, and can be achieved through impact exercise.
Lisa Gannon, Gannon, L, John Truscott, Emma Whatley, Carlton Cooke, Hind, K, Cooke, CB, Whatley, E, Whatley, Emma, Hind, Karen, Truscott, John, Karen Hind, Cooke, Carlton, Gannon, Lisa, Truscott, J   +14 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The critical appraisal of cross-sectional studies by using the JBI checklist for analytical cross-sectional studies (Moola et al., 2020).

, 2023
The critical appraisal of cross-sectional studies by using the JBI checklist for analytical cross-sectional studies (Moola et al., 2020).
Zhe Chi Loh (15333021), Zaheer-Ud-Din Babar (3131853), Jaya Muneswarao (13175962), Siew Chin Ong (9314213), Shamala Balan (15333024), Bandana Saini (590826), Rabia Hussain (195190)   +6 more
core   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source