Results 61 to 70 of about 1,589,263 (300)

Randomized controlled comparison of cross-sectional survey approaches to optimize follow-up completeness in clinical studies [PDF]

, 2019
IntroductionIn outcome research, incomplete follow-up is a major, yet potentially correctable source of bias. Cross-sectional surveys may theoretically increase completeness of follow-up, but low response rates are reported typically.
Christian Tinner, Jürg Schmidli, von Allmen, Regula S., Jürg Schmidli (384662), Florian Dick (455410), Hendrik T Tevaearai, Dick, Florian, Schmidli, Jürg, Florian Dick, Tinner, Christian, Regula S. von Allmen (814121), Christian Tinner (814124), Tevaearai, Hendrik T., Hendrik T. Tevaearai (142418), Regula S von Allmen   +14 more
core   +1 more source

Association between hip muscle cross-sectional area and hip pain and function in individuals with mild-to-moderate hip osteoarthritis:A cross-sectional study [PDF]

, 2020
Background: To examine the associations between hip muscle cross-sectional area and hip pain and function in community-based individuals with mild-to-moderate hip osteoarthritis.
Cicuttini, Flavia M., Peiris, Waruna L., Constantinou, M, Barrett, R, Wang, Y, Urquhart, Donna, Peiris, Waruna L, Wluka, Anita E., Kennedy, B, Cicuttini, Flavia M, Hussain, Sultana Monira, Kennedy, Ben, Wang, Yuanyuan, Constantinou, Maria, Barrett, Rod, Cicuttini, FM, Hussain, SM, Wluka, AE, Wluka, Anita E, Yaqobi, Abbas, Urquhart, D, Peiris, WL, Yaqobi, A   +22 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Characteristics of recreational substance consumption in night clubs in the Aburrá Valley

Revista Facultad Nacional de Salud Pública, 2011
Objective: to explore the demographic characteristics and the features of “recreational substance” consumption in people attending night clubs located in some of the municipalities of the Aburrá Valley.
Gloria I. Martínez D, Lina M. Martínez S, María A. Rodríguez G, Cristian C. Benítez R, Catalina Franco R   +4 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Quality assessment of cross-sectional studies using the ‘Appraisal tool of cross-sectional studies’ (AXIS).

Quality assessment of cross-sectional studies using the ‘Appraisal tool of cross-sectional studies’ (AXIS).
Peter Foley (8523412), Mark E. Bastin (7041269), Adam D. Waldman (10116784), Agniete Kampaite (11408699), Rebecka Gustafsson (18275606), Niall J. J. MacDougall (18275609), Elizabeth N. York (11408696), Siddharthan Chandran (94755), Rozanna Meijboom (7041257)   +8 more
core   +1 more source