Results 41 to 50 of about 3,322,440 (308)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Cross-sectional study of the provision of interventional oncology services in the UK [PDF]

, 2017
Objective: To map out the current provision of interventional oncology (IO) services in the UK. Design: Cross-sectional multicentre study. Setting: All National Health Service (NHS) trusts in England and Scottish, Welsh and Northern Ireland health ...
Alcorn, Des J., Atiiga, Peter, Breen, David J., Haslam, Philip J., Illing, Rowland, Kay, David, McCafferty, Ian J., Railton, Nicholas, Wah, Tze Min, Zhong, Jim   +9 more
core   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

A Cross Sectional Study of Trihexyphenidyl Utilization on Patient Receiving Antipsychotic Therapy [PDF]

, 2016
Background: Psychotic disorder becomes a mental health problem recently that reduce quality of life of the patient. As the matter of fact, psychotic treatment induce another problem such as extrapyramidal symtomps (EPS).
Azmi, A. N. (Addiniya), Desrini, S. (Sufi)   +1 more
core   +2 more sources

Cross‐sectional studies – what are they good for? [PDF]

Acta Obstetricia et Gynecologica Scandinavica, 2018
AbstractCross‐sectional studies serve many purposes, and the cross‐sectional design is the most relevant design when assessing the prevalence of disease, attitudes and knowledge among patients and health personnel, in validation studies comparing, for example, different measurement instruments, and in reliability studies.
openaire   +4 more sources

Quick assessment of hopelessness: a cross-sectional study [PDF]

Health and Quality of Life Outcomes, 2006
Lengthy questionnaires reduce data quality and impose a burden on respondents. Previous researchers proposed that a single item ("My future seems dark to me") and a 4-item component of the Beck's Hopelessness Scale (BHS) can summarise most of the information the BHS provides.
Cheung, YB, Yip, PSF
openaire   +7 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Paediatric malaria case-management with Artemether-Lumefantrine in Zambia: a repeat cross-sectional study [PDF]

, 2007
BACKGROUND Zambia was the first African country to change national antimalarial treatment policy to artemisinin-based combination therapy – artemether-lumefantrine.
Dejan Zurovac, Mickey Ndhlovu, Nawa Sipilanyambe, Pascalina Chanda, Davidson H Hamer, Jon L Simon, Robert W Snow, P Olumese, RW Snow, International Artemisinin Study Group, AK Rowe, AK Rowe, D Zurovac, DM Osterholt, F Font, N Nshakira, D Zurovac, AK Rowe, J Armstrong-Schellenberg, HM Bijl, National Malaria Control Centre, DH Hamer, D Zurovac, Central Board of Health, Central Board of Health, National Malaria Control Centre, National Malaria Control Centre, Central Board of Health, Central Board of Health, EM Malik, P Chanda, C Falade, Republic of Kenya, United Republic of Tanzania, Republic of Uganda, R Shretta, HA Williams   +36 more
core   +9 more sources

Experiences of cancer rehabilitation: A cross‐sectional study [PDF]

Journal of Clinical Nursing, 2018
Aims and objectivesTo investigate the cancer rehabilitation experiences of working‐age cancer survivors.BackgroundCancer survivors have extremely complex needs, spanning physical, vocational and sexual domains. Although cancer rehabilitation services have been found to eliminate or reduce these strains, these services are often underutilised.DesignA ...
Pernilla Garmy, Pernilla Garmy, Liselotte Jakobsson   +2 more
openaire   +5 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source