Results 51 to 60 of about 3,732,101 (308)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Natural environments and suicide mortality in the Netherlands: a cross-sectional, ecological study [PDF]

, 2018
Background: Natural outdoor environments, such as green spaces (ie, grass, forests, or parks), blue spaces (ie, visible bodies of fresh or salt water), and coastal proximity, have been increasingly shown to promote mental health.
de Beurs, Derek, Groenewegen, Peter P., Helbich, Marco, Kwan, Mei-Po, O'Connor, Rory C.   +4 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Risk Assessment For Clinical Attachment Loss In Periodontitis Patients

International Dental Journal
Aim or purpose: The purpose of this study was to assess the risk factors of clinical attachment loss (CAL) in periodontitis patients in different dental regions.
Shuo Liu
doaj   +1 more source

Food insecurity status and its contributing factors in slums’ dwellers of southwest Iran, 2021: a cross-sectional study [PDF]

, 2023
Hassan Joulaei, Parisa Keshani, Zohre Foroozanfar, Sima Afrashteh, Zahra Hosseinkhani, Mohammad Ali Mohsenpour, Ghasem Moghimi, Arash Homayouni Meymandi   +7 more
openalex   +1 more source

Gender assignment and gender agreement in advanced French interlanguage: a cross-sectional study [PDF]

, 2001
An analysis of 519 gender errors (out of 9,378 modifiers) in the advanced French interlanguage of 27 Dutch L1 speakers confirms earlier findings that gender assignment and/or agreement remain problematic for learners at all levels.
Dewaele, Jean-Marc, Véronique, D.
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A Study of Depression Among Aged in Surat City

National Journal of Community Medicine, 2010
This cross-sectional study interviews 105 elderly belonging to different socioeconomic and varying demographic groups of Surat city as per predefined inclusion and exclusion criteria with their informed consent in compliance with 'Ethical principles for
Vishal Jariwala, R K Bansal, Swati Patel, Bimal Tamakuwala   +3 more
doaj  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source