Results 101 to 110 of about 3,249,205 (265)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

A Mould Used for Manufacturing Metal Crosses Discovered in the Vicinity of the Episcopal Basilica from Histria

open access: yesMateriale și Cercetări Arheologice, 2014
A mould for manufacturing metal crosses was found during the 2013 excavations in the Centre-North sector from Histria, in a chamber located in the close proximity of the northern axis of the atrium of the Episcopal Basilica (1a).
Cliante, L.
doaj   +1 more source

Painting smock belonging to Stan Cross [realia] /

open access: yes, 1920
Title devised by cataloguer based on information from acquisition documentation.; Condition: Foxing, discolouration and stains.; Also available in an electronic version via the internet at: http://nla.gov.au/nla.pic-vn4461057.
Cross, Stan, 1888-1977.
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Things that make Stan cross [picture] : contending with the county council /

open access: yes, 1900
Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; "Stan Cross"--In ink, lower right. "Page 5"--In ink, on note attached to verso.; Title devised by cataloguer.; Also available in an electronic version via the internet at: http://nla ...
Cross, Stan, 1888-1977.
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Stan Cross' brother Hubert, a pearler from Broome, ca. 1950s [picture] /

open access: yes, 1950
Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Inscription: "Stan's brother Pearler from Broome"--In ink on verso.; Also available in an electronic version via the internet at: http://nla.gov.au/nla.pic ...
Cross, Stan, 1888-1977.
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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