Results 101 to 110 of about 251,458 (268)

The Impact on U.K. Acquirers of Domestic, Cross-border, Public and Private Acquisitions [PDF]

We examine the announcement and post-acquisition share returns of 4,000 acquisitions by U.K. public firms during 1984-1998. We include acquisitions of domestic and cross-border targets, and of both publicly quoted and privately held targets.
Andy Cosh, Alan Hughes, Paul M Guest, Robert L Conn   +3 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Driving Mechanisms and Spatial Variations of Soil C:N:P Stoichiometry in Desert Steppe of the Ili River Basin, Northwest China

Agriculture
Soil stoichiometric characteristics, as sensitive indicators of soil nutrient supply capacity and ecosystem stability, have emerged as a frontier research focus in biogeochemical cycling and ecological studies.
Tiantian Wu, Yanxin Yang, Shiya He, Lan Lan, Ziying Jiangalike, Xuhui Tang, Adilaimu Abulaiti, Xiaofang Ye, Fei Yu, Huixia Liu   +9 more
doaj   +1 more source

Demand and Distance: Evidence on Cross-Border Shopping [PDF]

While many studies have documented deviations from the Law of One Price in international settings, evidence is scarce on the extent to which consumers take advantage of price differentials and engage in cross border shopping. We use data from 287 Swedish
Friberg, Richard, Wilander, Fredrik, Asplund, Marcus   +2 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Cross-border and local cooperation on the island of Ireland : an economic perspective

, 2006
Revised version of a paper presented at a study group meting in Newry, 13 September 2005, as part of the programme Mapping frontiers, plotting pathways: routes to North-South cooperation in a divided island.Cross-border and local cooperation can foster
Roper, Stephen
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Nutrigenomic insights and cardiovascular benefits of blackberry (Rubus ulmifolius Schott.) and mugwort (Artemisia campestris L.)

Experimental Physiology
Blackberry (Rubus ulmifolius Schott) and mugwort (Artemisia campestris L.) are plants traditionally used to treat various pathologies, including hypertension. The vasodilatory and hypotensive effects of blackberry were investigated through experiments in
Afaf Mehiou, Anca Lucau‐Danila, Zachee L. E. Akissi, Chaimae Alla, Nourelhouda Bouanani, Abdelkhaleq Legssyer, Jean‐Louis Hilbert, Sevser Sahpaz, Abderrahim Ziyyat   +8 more
doaj   +1 more source

The modified mRNA vaccine protects immunocompromised AG129 mice from lethal challenge and multi-tissue infection by Zika virus

Emerging Microbes and Infections
The multiple epidemics of Zika virus (ZIKV) posed a substantial threat to public health. Clinical evidence suggests that ZIKV could break through the blood–brain, blood-placenta, and blood-testis barriers, leading to severe outcomes such as congenital ...
Yuhuan Yan, Junbin Wang, Hao Yang, Yun Yang, Longhai Yuan, Cong Tang, Yanan Zhou, Qing Huang, Wenhai Yu, Xiaoming Liang, Dongdong Lin, Yanwen Li, Xuena Du, Yuxia Yuan, Rui Peng, Jiali Xu, Zhaolan Guo, Wenhao Xie, Wenqi Quan, Hongyu Chen, Jian Zhou, Shuaiyao Lu, Xiaozhong Peng   +22 more
doaj   +1 more source