Results 91 to 100 of about 673,192 (251)

An Accurate Discrete Current Controller for High-Speed PMSMs/Gs in Flywheel Applications

open access: yesEnergies, 2020
High-speed Permanent-Magnet Synchronous Motors/Generators (PMSMs/Gs) in a Flywheel Energy Storage System (FESS) are faced with high cross-coupling voltages and low switching-to-fundamental frequency ratios.
Xiang Zhang   +4 more
doaj   +1 more source

Fluid Intelligence and the Cross-Frequency Coupling of Neuronal Oscillations

open access: yesThe Spanish Journal of Psychology, 2016
AbstractSeveral existing theoretical models predict that the individual capacity of working memory and abstract reasoning (fluid intelligence) strongly depends on certain features of neuronal oscillations, especially their cross-frequency coupling.
openaire   +3 more sources

Phase-amplitude coupling and epileptogenesis in an animal model of mesial temporal lobe epilepsy

open access: yesNeurobiology of Disease, 2018
Polyrhythmic coupling of oscillatory components in electrophysiological signals results from the interactions between neuronal sub-populations within and between cell assemblies.
Soheila Samiee   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A Sleep Disorder Detection Model based on EEG Cross-Frequency Coupling and Random Forest

open access: yesmedRxiv, 2020
Study objectives: Sleep disorders are medical disorders of the sleep architecture of a subject, and based on their severity they can interfere with mental, emotional and physical functioning.
S. Dimitriadis   +2 more
semanticscholar   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Spatiotemporal characteristics and pharmacological modulation of multiple gamma oscillations in the CA1 region of the hippocampus

open access: yesFrontiers in Neural Circuits, 2015
Multiple components of γ-oscillations between 30-170 Hz in the CA1 region of the hippocampus have been described, based on their coherence with oscillations in other brain regions and on their cross-frequency coupling with local θ-oscillations.
Shilpa eBalakrishnan   +2 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

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