Results 91 to 100 of about 1,035,512 (307)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Guidelines for Prevention of Nosocomial Pneumonia [PDF]

"This document updates and replaces CDC's previously published "Guideline for Prevention of Nosocomial Pneumonia" (Infect Control 1982;3:327-33, Respir Care 1983;28:221-32, and Am J Infect Control 1983;11:230-44).

core  

Ascaris lumbricoids Infection as a Risk Factor for Asthma and Atopy in Rural Bangladeshi Children. [PDF]

, 2014
Controversy persists as to whether helminth infections cause or protect against asthma and atopy. The aim of this study was to investigate the effects of helminth infection on asthma and atopy among Bangladeshi children.
Persson, Lars Å, Noguchi, Emiko,, Itoh, Makoto,, Noguchi, Emiko, Wagatsuma, Yukiko,, Raqib, Rubhana,, Wagatsuma, Yukiko, Ma, Enbo, Moore, Sophie E; id_orcid, Moore, Sophie E,, Moore, Sophie E, Persson, Lars-Åke,, Raqib, Rubhana, Hawlader, Mohammad D H, Hawlader, Mohammad D H,, Arifeen, Shams E,, Arifeen, Shams E, Ma, Enbo,, Itoh, Makoto, Hawlader, Mohammad DH   +19 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

A scoping review of published reports of the infection prevention and control assessment framework: a comparison to the findings of the global report on infection prevention and control [PDF]

Background: The World Health Organization (WHO) published the Global Report on Infection Prevention and Control (IPC) in 2022, highlighting both achievements and areas for improvement in IPC practices globally.
Zimmerman, Peta-Anne, Mason, Matt
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Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection [PDF]

, 2008
Background: It has frequently been reported that Plasmodium vivax suppressed Plasmodium falciparum and ameliorated disease severity in patients infected with these two species simultaneously.
Kimura-Sato, M, Chavalitshewinkoon-Petmitr, P, Kimura-Sato Masako, Porntip Chavalitshewinkoon-Petmitr, de Souza, J Brian, Sornchai Looareesuwan, Polrat Wilairatana, Srivicha Krudsood, Tan-Ariya, Peerapan, Thongrungkiat, S, Thongrungkiat, Supatra, Thongrungkiat Supatra, Looareesuwan Sornchai, Peerapan Tan-ariya, Ishida, T, Tan-Ariya, P, Chavalitshewinkoon-Petmitr, Porntip, Krudsood, Srivicha, Ishida Takafumi, Yoshiro Nagao, Masako Kimura-Sato, de Souza, JB, Kimura-Sato, Masako, Tan-ariya Peerapan, Looareesuwan, S, Nagao Yoshiro, Looareesuwan, Sornchai, Nagao, Y, Krudsood, S, Krudsood Srivicha, Chavalitshewinkoon-Petmitr Porntip, de Souza J Brian, Nagao, Yoshiro, Wilairatana Polrat, Takafumi Ishida, Supatra Thongrungkiat, Wilairatana, Polrat, J Brian de Souza, Ishida, Takafumi, Wilairatana, P   +39 more
core   +1 more source

Candida auris, an Emerging Fungal Pathogen

Journal of Mazandaran University of Medical Sciences, 2019
The emerging pathogen “Candida auris” is attracting considerable international attention due to its rising reports, transmission through health professionals, high rate of treatment failure and resistance to multiple antifungal agents, particularly ...
Shahram Mahmoudi, Kazem Ahmadikia, Mohammad Kord, Ali Ahmadi, Sadegh Khodavaisy   +4 more
doaj  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Mannose-binding lectin 2 polymorphisms do not influence frequency or type of infection in adults with chemotherapy induced neutropaenia. [PDF]

, 2012
BACKGROUND: Mannose-binding Lectin protein (MBL) has been suggested to be relevant in the defence against infections in immunosuppressed individuals.
Öhrmalm, Lars, Michelle Wong, Ohrmalm, L, Öhrmalm L., Lars Öhrmalm, Aust Carl, Tolfvenstam, Thomas, Tolfvenstam T., Hibberd, Martin, Wong, Michelle, Martin Hibberd, Hibberd M., Broliden K., Tolfvenstam, T,, Hibberd, M, Kristina Broliden, Thomas Tolfvenstam, Broliden, K,, Broliden, Kristina, Hibberd Martin, Broliden Kristina, Aust, C,, Wong, M, Carl Aust, Aust C., Wong M., Tolfvenstam Thomas, Öhrmalm Lars, Wong Michelle, Aust, Carl   +29 more
core   +1 more source