Results 71 to 80 of about 1,030,546 (307)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Spatial mapping and prediction of Plasmodium falciparum infection risk among school-aged children in Côte d'Ivoire [PDF]

, 2016
BACKGROUND: In Côte d'Ivoire, malaria remains a major public health issue, and thus a priority to be tackled. The aim of this study was to identify spatially explicit indicators of Plasmodium falciparum infection among school-aged children and to ...
Silué, Kigbafori D., Eveline Hürlimann, Eliézer K. N’Goran, N'Dri, Prisca B., Assi, Serge-Brice, Utzinger, Jürg, Yapi, Richard B., Frédérique Chammartin, Chammartin, Frédérique, Penelope Vounatsou, Prisca B. N’Dri, Benjamin G. Koudou, N’Goran, Eliézer K., Richard B. Yapi, Fantodji, Agathe, Silué, Kigbafori D, Jürg Utzinger, Houngbedji, Clarisse A., Giovanna Raso, Kigbafori D. Silué, Koudou, Benjamin, Raso, Giovanna, Gotianwa Soro, Koudou, Benjamin G., Houngbedji, Clarisse A, N’Dri1, Prisca B, Clarisse A. Houngbedji, Serge-Brice Assi, Soro, Gotianwa, N'Goran, Eliézer K., Hürlimann, Eveline, Vounatsou, Penelope, Agathe Fantodji   +32 more
core   +1 more source

Evaluation of the Etiology of Nosocomial Pneumonia in the ICUs of the Teaching Hospitals of Hamadan University of Medical Sciences

پزشکی بالینی ابن سینا, 2011
Introduction & Objective: Nosocomial pneumonia is pneumonia that occurs at least 48 hours after hospitalization. In total, this infection is the second most common cause of hospital-acquired infection in intensive care units.
Ebrahim Nadi, Babak Nekoie, Ahmadreza Mobaien, Abbas Moghimbeigi, Arash Nekoie   +4 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Guidance on public reporting of healthcare-associated infections: recommendations of the Healthcare Infection Control Practices Advisory Committee [PDF]

"Embargoed until Monday, February 28, 2005 at 12:30 pm."Since 2002, 4 states have enacted legislation that requires health care organizations to publicly disclose health care-associated infection (HAI) rates.
Hospital Infection Control Practices Advisory Committee (U.S.)
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The NHSN standardized infection ratio (SIR) : a guide to the SIR [PDF]

Updated April 2022.The Standardized Infection Ratio (SIR) is the primary summary measure used by the National Healthcare Safety Network (NHSN) to track healthcareassociated infections (HAIs).

core   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Human Schistosome Infection and Allergic Sensitisation [PDF]

, 2012
Several field studies have reported an inverse relationship between the prevalence of helminth infections and that of allergic sensitisation/atopy. Recent studies show that immune responses induced by helminth parasites are, to an extent, comparable to ...
Francisca Mutapi, Mutapi, Francisca, Nadine Rujeni, Rujeni, Nadine, David W. Taylor, Taylor, David W.   +5 more
core   +1 more source

Elimination of Cross-infection [PDF]

BMJ, 1945
H P, Pickerill, C M, Pickerill
openaire   +2 more sources