Results 131 to 140 of about 8,915,614 (369)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Caracterización de pacientes con bronconeumonía bacteriana asociada a la ventilación artificial mecánica

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2015
Fundamento: las neumonías nosocomiales constituyen hoy en día un problema de salud a nivel mundial. En las unidades de cuidados intensivos de las instituciones hospitalarias ingresa un elevado número de pacientes que requieren ventilación artificial ...
Danilo Eranio Utra Cardoso, Leonila Atencio González, Aida Esther Leyva Peña, Gladis Marrero Ávila, Idalia Arcias Castillo   +4 more
doaj  

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Evaluation of the Etiology of Nosocomial Pneumonia in the ICUs of the Teaching Hospitals of Hamadan University of Medical Sciences

پزشکی بالینی ابن سینا, 2011
Introduction & Objective: Nosocomial pneumonia is pneumonia that occurs at least 48 hours after hospitalization. In total, this infection is the second most common cause of hospital-acquired infection in intensive care units.
Ebrahim Nadi, Babak Nekoie, Ahmadreza Mobaien, Abbas Moghimbeigi, Arash Nekoie   +4 more
doaj  

Peer Review Report For: Inflammatory markers in patients who presented with acute coronary syndrome and history of COVID-19 infection: a cross-sectional study [version 1; peer review: 1 approved with reservations, 1 not approved] [PDF]

, 2022
Srikanth Umakanthan
openalex   +1 more source

A Cross-Reactive Humanized Monoclonal Antibody Targeting Fusion Glycoprotein Function Protects Ferrets Against Lethal Nipah Virus and Hendra Virus Infection

Journal of Infectious Diseases, 2019
Background Nipah virus (NiV) and Hendra virus (HeV) are zoonotic paramyxoviruses that cause severe disease in both animals and humans. There are no approved vaccines or treatments for use in humans; however, therapeutic treatment of both NiV and HeV ...
C. Mire, Y. Chan, V. Borisevich, R. Cross, Lianying Yan, K. Agans, H. Dang, D. Veesler, Karla A. Fenton, T. Geisbert, C. Broder   +10 more
semanticscholar   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Application of a New Type of Protective Sputum Suction Device in Clinic against Cross-Infection between Medical Staff and Patients. [PDF]

Crit Care Res Pract, 2023
Lu K, Wu W, Jin G, Yang H, Cai X, Li L, Chen Z, Ren L, Guo B, Xue QF.   +9 more
europepmc   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source