Results 31 to 40 of about 1,584,633 (272)

MERS-CoV (Middle East Respiratory Syndrome Coronavirus) outside the Arabian Peninsula an One Health approach: Understanding the role of wildlife, livestock and human in the virus dynamic [PDF]

, 2016
One of the big paradoxes of the MERS-CoV epidemiology is the apparent lack of human cases in large parts Africa where the virus and an animal host, the dromedary camel, are present.
Akhmetsadykov, Nourlan, Ayelet, Gelagay, Baubekova, Almagul, Ben Bencheikh, M.N., Bourgarel, Mathieu, Boussini, H., Chevalier, Véronique, Chu, Daniel K.W., El Berbri, Ikhlass, Fassi-Fihri, Ouafaa, Faye, Bernard, Fekadu, G., Grosbois, Vladimir, Maher, W., Miguel, Eve, Peiris, Malik, Perera, Ranawaka A.P.M., Roche, Benjamin, Roger, François, Shimekit, D., Traoré, Amadou, Van Kerkhove, Maria D.   +21 more
core  

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Controversies in cross-infection control' [PDF]

British Dental Journal, 1993
The following article is intended to question certain procedures designed to prevent cross-infection. It is the first of a series of occasional articles describing new techniques, research, and new products, which it is hoped, may enable dental practitioners to update their knowledge of this rapidly changing subject.
openaire   +5 more sources

Cross-protection against European swine influenza viruses in the context of infection immunity against the 2009 pandemic H1N1 virus : studies in the pig model of influenza [PDF]

, 2015
Pigs are natural hosts for the same influenza virus subtypes as humans and are a valuable model for cross-protection studies with influenza. In this study, we have used the pig model to examine the extent of virological protection between a) the 2009 ...
A Krumbholz, A Lavenu, AC Lowen, AI Karasin, AR Vleeschauwer De, AS Monto, B Brandenburg, B Manicassamy, B Srivastava, CD O’Donnell, CD O’Donnell, CS Kyriakis, CS Kyriakis, DM Skowronski, ED Kilbourne, G Simon, GA Landolt, GG Brownlee, I Skountzou, IH Brown, JC Kash, JH Kreijtz, JL Schulman, K Hoschler, K Reeth Van, K Reeth Van, K Reeth Van, K Reeth Van, K Tamura, Karl De hert, KL Laurie, Kristien Van Reeth, L Campitelli, M Khatri, M Pensaert, M Retamal, M Strengell, MA Marco De, MI Nelson, MJ Sylte, ML Hillaire, MR Castrucci, MR Castrucci, MR Sandbulte, N Busquets, NM Bouvier, PM Colman, PP Heinen, RA Perera, RA Yetter, RJ Garten, S Liang, SL Epstein, SM Brookes, T Sonoguchi, TM Straight, Y Qiu, Y Qiu, Yu Qiu   +58 more
core   +6 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Leprosy and tuberculosis concomitant infection: a poorly understood, age-old relationship [PDF]

, 2014
Historically, archaeological evidence, post-mortem findings and retro- spective analysis of leprosy institutions’ data demonstrates a high observed incidence of concomitant infection with leprosy and tuberculosis (TB).
Anjum, V, Hodgson, J, Murthy, K, Rao, AK, Rao, PS, Rao, PV, Rawson, T, Subbanna, J   +7 more
core  

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source