Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cross-protection induced by VA-MENGOC-BC® vaccine
Human Vaccines & Immunotherapeutics, 2018 I would like to comment on the article “Commentary: Impact of meningococcal group B OMV vaccines, beyond their brief”, DOI: 10.1080/21645515.2017.1381810.
R. Ochoa-Azze
semanticscholar +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Study of cross protection of citrus tristeza viruse disease on Bendizao mandarin (Citrus succosa)
浙江大学学报. 农业与生命科学版, 2005 The disease samples were collected from over 20-year old trees of Bendizao mandarin (Citrus succosa) in Huangyan, Zhejiang Province, China during 1995-1996. Eighteen CTV (Citrus tristeza virus) isolates were identified on the indicator plant Mexican lime
CUI Bo-fa +4 more
doaj +1 more source
Review on Privacy Protection of Electronic Medical Data in Cross-domain Sharing
, 2023 Yue Zhang, Mingchuan Zhang
openalex +2 more sources
Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria [PDF]
, 2015 BACKGROUND Sporozoite immunization of animals and humans under a chemo-prophylactic cover of chloroquine (CPS-CQ) efficiently induces sterile protection against malaria.
Bijker, Else M +5 more
core +2 more sources
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Investor Protection and Foreign Stakeholders [PDF]
Different investor classes are endowed with different rights, and conflicting interests among them can make protections afforded to one party detrimental to another.
Maela Giofré
core
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Universal Influenza Vaccines, a Dream to Be Realized Soon
Viruses, 2014 Due to frequent viral antigenic change, current influenza vaccines need to be re-formulated annually to match the circulating strains for battling seasonal influenza epidemics.
Han Zhang +3 more
doaj +1 more source