Results 51 to 60 of about 708,583 (355)
, 2023 Paired redox-neutral electrolysis offers an attractive green platform for organic synthesis by avoiding sacrificial oxidants and reductants. Here, we report the electro/Ni dual-catalyzed redox-neutral C(sp3)−C(sp2) cross-coupling reactions between ...
Daniel, Ess +3 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 2016 Cross-Coupling Reactions of Aryl Chlorides with Organochlorosilanes: Highly Effective Methods for Arylation or Alkenylation of Aryl ...
Yasuo Hatanaka (1412941) +3 more
core +1 more source
Memorias do Instituto Oswaldo Cruz, 2009 To improve the serodiagnosis of human toxocariasis, a sensitive and specific enzyme-linked immunoelectrotransfer blot (EITB-IgG) test was developed and evaluated using Toxocara canislarvae excretory-secretory antigens for detecting anti-Toxocara IgG ...
William H Roldán, Yrma A Espinoza
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Nickel-catalyzed cross-coupling reactions through C-O and C-N bond activation
, 2020 Watson, Mary P.This dissertation focuses on nickel-catalyzed cross-couplings of amine and alcohols via C–N and C–O bond activation. Chapter 1 focuses on the development of a stereospecific, nickel-catalyzed Suzuki-Miyaura cross-coupling of allylic ...
Hoerrner, Megan E.
core +1 more source
Ligand-Enabled Gold-Catalyzed C(sp2)–O Cross-Coupling Reactions
, 2023 Reported herein is a ligand-enabled gold-catalyzed C(sp2)-O cross-coupling reaction of aryl iodides and aliphatic alcohols. The synthesis of a variety of aryl alkyl ethers including complex biomolecules and various medicinally relevant motifs has been ...
Avishek, Das, Nitin T., Patil
core +1 more source
N-Vinylation of Imidazole and Benzimidazole with a Paramagnetic Vinyl Bromide
Molbank, 2018 An N-vinylation of imidazole and benzimidazole with a paramagnetic vinyl bromide was investigated. Among the tested procedures, Pd-catalyzed reaction was the most powerful one.
Györgyi Úr +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Nature CommunicationsThe (hetero)aryl sulfoximines are important structures for developing bioactive molecules, whose synthesis relies on oxidation of (hetero)aryl sulfilimines. However, asymmetric approaches for assembling (hetero)aryl sulfilimines are still rare.
Mingchuang He +4 more
doaj +1 more source