Results 181 to 190 of about 30,931 (235)

Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment‐Resistant Wounds

Advanced Science, EarlyView.
Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn, Joo Hun Lee, Christian Hurd, Jiye Lee, Junggeon Park, Adam A. Markowicz, Zheyuan Zhang, Joanne Hwang, Guillermo L. Monroy, Simon A. Rogers, Woonggyu Jung, Stephen A. Boppart, Hyunjoon Kong   +12 more
wiley   +1 more source

Patient-derived organotypic tumor spheroids as a functional platform for predicting immunotherapeutic responses and guiding precision treatment for hepatocellular carcinoma. [PDF]

J Immunother Cancer
Song F, Lu YJ, Sun HX, Cheng JW, Li WZ, Liu Z, Li RZ, Wang PX, Zheng WJ, Zhong YC, Xu Y, Xu J, Wang Y, Bai SY, Xie L, Man K, Fan J, Zhou J, Chen Z, Yang XR.   +19 more
europepmc   +1 more source

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

Advanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee, Jumi Kim, Taehan Yoon, So Hyun Kwon, Su Chan Park, Dohyun Chun, Dohyeong Kim, Eun Jung Park, Hyunwoo Kim, Ji Min Lee   +9 more
wiley   +1 more source

Perineural invasion in solid tumors: biological foundations and the emerging integration of machine learning and artificial intelligence. [PDF]

Front Oncol
Bahmad HF, Mirzabeigi Y, Elajami YK, Abou-Kheir W, Nair N.   +4 more
europepmc   +1 more source

Machine‐Learning‐Enhanced Printed Vertical Magnetoresistive Sensors for Transparent, Flexible, Multimodal Interactive Magnetoelectronics

Advanced Science, EarlyView.
This study presents printed magnetoresistive sensors with a vertically aligned architecture that enables high optical transparency and mechanical flexibility. By integrating deep learning for the analysis of complex spatiotemporal signal patterns, the system further achieves intelligent multimodal interaction capabilities.
Rui Xu, Guannan Mu, Oleksandr V. Pylypovskyi, Qihao Zhang, Rico Illing, René Hübner, Ran He, Andreas Knüpfer, Sebastian Lehmann, Olha Bezsmertna, Kornelius Nielsch, Denys Makarov   +11 more
wiley   +1 more source

Automated calculation of background parenchymal enhancement as a biomarker of treatment responses and recurrence-free survival in breast cancer. [PDF]

Breast Cancer Res Treat
Zhu Y, Hadidchi R, Nguyen HQ, Hariharan S, Weiss J, Hou W, Chung C, Luu HM, Ragupathi S, Maldjian T, Duong TQ.   +10 more
europepmc   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Mass Spectrometric Detected Cancer Proteins as Resources for Cancer Research. [PDF]

J Proteome Res
Huang Y, Chen L, Wu PI, Juneja P, Chen L, Evrard YA, Jiao L, Hu Y, Zhang X, Doroshow JH, Thangudu RR, Pilozzi A, Zhang H.   +12 more
europepmc   +1 more source

Inside‐Outside ROS Therapeutic Strategy Based on Piezoelectric Nano‐Urchin for Drug‐Resistant Bacteria Biofilm Infections

Advanced Science, EarlyView.
The contribution of this study lies not only in enabling effective treatment of drug‐resistant biofilm infections, but also in establishing a transferable therapeutic paradigm: Ultrasound‐triggered mechanical forces synergistically enhance piezoelectric polarization and nanozyme activity, driving functional ROS generation inside and outside biofilms ...
Xinjian Guo, Jin Yang, Mengjie An, Bingjie Lin, Tao Liu, Limin Zhang   +5 more
wiley   +1 more source

Risk factor identification and nomogram-based predictive model development for recurrence of pituitary adenomas following transsphenoidal surgery: a dual-center retrospective study. [PDF]

Front Surg
Yang X, Yang W, Hou P, Chen Y, Li J, Zhong J, Wang S, Chen H.   +7 more
europepmc   +1 more source