Results 191 to 200 of about 30,931 (235)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Non-Linear Center-of-Pressure Features Associated with Fall History in Older Adults: An Exploratory Analysis. [PDF]

Sensors (Basel)
Wakabayashi D, Okada Y.
europepmc   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Density-adjusted analysis of cell interactions to decipher tissue landscape changes. [PDF]

iScience
Siddiqui M, Hamidinekoo A, Tan JY, Leke R, Zarrouki B, Trahearn N, Hagos YB, Sakr C, Lampis A, Bagnall C, Pellegrini G, Castillo SP, Challis B, Yuan Y, Bezzi M, Ling S.   +15 more
europepmc   +1 more source

Tumor Budding in Colorectal Carcinoma-From Incidental Observation to Prognostic Marker: Lessons Learned from Colorectal Cancer Assessment. [PDF]

Medicina (Kaunas)
Ciobănoiu AD, Grigorean VT, Pleşea IE, Pleșea RM, Erchid A.   +4 more
europepmc   +1 more source

Neoadjuvant BO-112 and Hypofractionated Radiation Therapy with or without Nivolumab in Soft-Tissue Sarcoma: Preclinical and Phase I Results. [PDF]

Cancer Discov
Deng J, Pal A, Testa S, Xu JW, Tran LM, Graham DS, Hargil A, Subramanian A, Campbell KM, Limsuwannarot S, Chumpitaz Lavalle Á, Chin SC, Kremer S, Tariveranmoshabad M, Ewongwo A, Silvia SKNR, Ogana H, Nemat-Gorgani N, Dubinett SM, Jaycox JR, Felix C, Schaue D, Nelson SD, Levine B, Motamedi K, Ghazikhanian V, Chmielowski B, Reddy V, Singh AS, Trnkova ZJ, Good Z, Quintero M, Crompton JG, Bernthal N, Eilber FC, Moding EJ, Kalbasi A.   +36 more
europepmc   +1 more source

Evaluating Molecular and Immune Biomarkers in Predicting Bladder Cancer Recurrence and Survival: A Systematic Review. [PDF]

Cureus
Masood S, Shaikh A, Brar Y.
europepmc   +1 more source

A combined radiomics and habitat analysis model for predicting early recurrence of HCC after liver transplantation. [PDF]

Front Oncol
Yang Y, Luo Y, Liu H, Wang M, Xiao X, Zhang L, Su X, Shi B, Wang J, Xie H.   +9 more
europepmc   +1 more source

Chromatic and Anisotropic Cross-Recurrence Quantification Analysis of Interpersonal Behavior [PDF]

Springer Proceedings in Physics, 2016
Cross-recurrence quantification analysis (CRQA) is a powerful nonlinear time-series method to study coordination and cooperation between people. This chapter concentrates on two methodological issues related to CRQA on categorical data streams, which are commonly encountered in the behavioral sciences. Firstly, we introduce a more general definition of
Marijn Van Dijk, Lisette De Jonge-Hoekstra, Ralf Cox   +2 more
exaly   +3 more sources