Results 41 to 50 of about 6,666,651 (303)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Non-Linear Dynamics Analysis of Protein Sequences. Application to CYP450

Entropy, 2019
The nature of changes involved in crossed-sequence scale and inner-sequence scale is very challenging in protein biology. This study is a new attempt to assess with a phenomenological approach the non-stationary and nonlinear fluctuation of changes ...
Xavier F. Cadet, Reda Dehak, Sang Peter Chin, Miloud Bessafi   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An efficient connected dominating set algorithm in WSNs based on the induced tree of the crossed cube

International Journal of Applied Mathematics and Computer Science, 2015
The connected dominating set (CDS) has become a well-known approach for constructing a virtual backbone in wireless sensor networks. Then traffic can forwarded by the virtual backbone and other nodes turn off their radios to save energy.
Zhang Jing, Zhou Shu-Ming, Xu Li, Wu Wei, Ye Xiucai   +4 more
doaj   +1 more source

Noise suppression in PD signal based on Prony time series energy spectrum

IET Science, Measurement & Technology, 2022
On‐line partial discharge (PD) monitoring is related to the safe and stable operation of power grid. However, the measured signal is inevitably affected by noise. Among a variety of noises, white noise is the most difficult to suppress and ubiquitous. It
Chang Wang, Chunxiao Yu, Qin Shu, Dakun Zhang, Yuhang He   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Localization of Compact Circularly Polarized RFID Tag Using ToA Technique [PDF]

Radioengineering, 2017
A compact, flexible crossed-dipole circular polarized antenna using commercially available paper substrate is presented which caters North American frequency band.
U. H. Khan, H. Rasheed, B. Aslam, A. Fatima, L. Shahid, Y. Amin, H. Tenhunen   +6 more
doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Experimental and LES Studies of Propane–air Premixed Gases in Pipelines Containing Mixed Obstacles [PDF]

Journal of Applied Fluid Mechanics
This study investigated the effect of a mixed obstacle layout on the deflagration mechanism of propane–air premixed gases. Most previous studies focused on a single type of obstacle, changing the shape and number of the obstacles to observe the effect on
Y. Wu, J. Gao, Y. Han, B. Ai, X. Shao, B. Guo, B. Hao   +6 more
doaj   +1 more source