Results 181 to 190 of about 364,075 (332)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Fine-Structure Map of the Histidine Transport Genes in \u3cem\u3eSalmonella typhimurium\u3c/em\u3e [PDF]

open access: yes, 1977
Afine-structure genetic map of the histidine transport region of the Salmonella typhimurium chromosome was constructed. Twenty-five deletion mutants were isolated and used for dividing the hisJ and hisP genes into 8 and 13 regions respectively.
Afong, J.   +6 more
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

Genetic variability in sesame (Sesamum indicum L.) [PDF]

open access: yesElectronic Journal of Plant Breeding, 2012
Genetic parameters of variability and heritability of different characters were studied in four crosses of sesame. In the presentstudy, variability parameters were observed in two crosses viz., Paiyur 1 x SVPR 1, F2 of TMV 4 x SVPR 1 and their BC1F1s ...
Revathi, S., John Joel, A. and Manivannan, N
doaj  

Selective breeding program for genetic improvement of Macrobrachium rosenbergii in Thailand. [PDF]

open access: yes, 2005
Although the giant freshwater prawn (Macrobrachium rosenbergii) has been domesticated in Thailand for over decades, appropriate selective breeding program has yet to be achieved. Good quality seeds for the Machrobrachium aquaculture industry is therefore
Sodsuk, Panom K.   +1 more
core   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

open access: yesFEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal   +3 more
wiley   +1 more source

Using genotyping-by-sequencing to understand Musa diversity : [P449] [PDF]

open access: yes, 2014
This project is part of a larger effort to apply genomics technologies to assess genetic diversity and to advance genetic improvement efforts in Musa (banana and plantain), a major staple food crop in the developing world.
Chan, Agnes P.   +6 more
core  

Dysfunctional tetraspanin 7 (TSP‐7) in Caenorhabditis elegans promotes; increases in average life‐ & health‐span, stress‐induced survival and motility

open access: yesFEBS Open Bio, EarlyView.
The C. elegans tetraspanin‐7 (tsp‐7) is a homologue of human CD63, which is a negative regulator of autophagy. The C. elegans strain, tm5761, has a dysfunctional (knockout) tsp‐7 gene. When compared to the wild‐type strain, the tm5761 strain shows increased: life‐ and health‐span; thermotolerance, and stress‐induced locomotion.
Brogan Jones   +2 more
wiley   +1 more source

Genetic parameters assessment of siliquae associated with stress indices in rapeseed cultivars

open access: yesAgronomy Science, 2012
The objective of the present study was to determine the genetic control and heritability of siliquae per plant at two places including without and application of nitrogen (Pp and Ps) and its related stress tolerance indices based on half diallel crosses ...
VALIOLLAH RAMEEH
doaj  

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