Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
On a generalisation of the Banach indicatrix theorem
, 2016 We prove that for any regulated function $f:\left[a,b\right]\rightarrow\mathbb{R}$ and $c\geq 0$ the infimum of the total variations of functions approximating $f$ with accuracy $c/2$ is equal $\int_{\mathbb{R}} n_{c}^{y} \mathrm{d} y,$ where $n_{c}^{y}$
Łochowski, Rafał M.
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Exterior characteristics and coat colour marker of MC1R gene in Bali Crossbred cattle
Journal of the Indonesian Tropical Animal AgricultureCrossbreeding between Bali cattle with exotic bulls (such as Simmental and Limousin) has been widely developed in several regions in Indonesia. This study aims to determine changes in exterior characteristics and differences in vital statistics of Bali ...
G. M. Swasti +4 more
doaj +1 more source
Geneticl nlysis of ginning outturn and fiber properties in crosses in hirsutum cotton [PDF]
Kirkuk Journal of Science, 2007 Half diallel crosses (excluded reciprocals) carried out among nine upland cotton varieties (Halab1, SP8886, Dunn1517, Cocker5114, Deltapine5409, Lachata, Dunn1047, Cocker310 and Deer22). Genotypes were planted using RCBDesign with 3 replications and data
doaj +1 more source
, 2015 I grew up in a country where I was part of a religion practiced by few, while always surrounded by people who were like me. We had constant gatherings filled with music and food. There were bright, colorful, weddings that spanned four or five days. There
Ramaiya, Jhanvi C.
core
Rare variants contribute disproportionately to quantitative trait variation in yeast. [PDF]
, 2019 How variants with different frequencies contribute to trait variation is a central question in genetics. We use a unique model system to disentangle the contributions of common and rare variants to quantitative traits.
Bloom, Joshua S +6 more
core +1 more source
Surface gravity and Hawking temperature from entropic force viewpoint
, 2010 We consider a freely falling holographic screen for the Schwarzschild and Reissner-Nordstr\"om black holes and evaluate the entropic force \`a la Verlinde.
Carroll S. M. +4 more
core +1 more source
The effects of disruptive and stabilizing selection on body size in Drosophila melanogaster. III. Genetic analysis of two lines with different reactions to disruptive selection with mating of opposite extremes [PDF]
, 1974 A genetic analysis was made of two lines which when subjected to disruptive selection with compulsary mating of opposite extremes (D−) showed a different response viz.
Bos, M., Scharloo, W.
core +3 more sources
Cross-Linguistic Syntactic Difference in Multilingual BERT: How Good is It and How Does It Affect Transfer? [PDF]
, 2022 Ningyu Xu +6 more
openalex +1 more source