Results 131 to 140 of about 9,924,168 (281)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over. [PDF]

Mol Cell, 2020
He W, Rao HBDP, Tang S, Bhagwat N, Kulkarni DS, Ma Y, Chang MAW, Hall C, Bragg JW, Manasca HS, Baker C, Verhees GF, Ranjha L, Chen X, Hollingsworth NM, Cejka P, Hunter N.   +16 more
europepmc   +1 more source

Controlled crossing-over [PDF]

Nature Reviews Molecular Cell Biology, 2004
openaire   +1 more source

Kick it over - No. 08 (September 1983)

, 1983
A social anarchist and anti-authoritarian quarterly publication. In this issue: "1984 preview issue" - Welfare warfare, No cheating birth control, Politics of pot, Pork pressure in T.O., Aborting the right, Spy bill, Agent orange, Books & records ...

core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Kick it over - No. 18 (Spring 1987)

, 1987
A social anarchist and anti-authoritarian quarterly publication. In this issue: "Anarcha-feminism" - Interview with Lizzie Borden, Herstory of anarcha-feminism, Genital mutilation, Greenham Common memoirs, The "other" womyn's music, Women in ...

core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Kick it over - No. 07 (May 1983)

, 1983
A social anarchist and anti-authoritarian quarterly publication. In this issue: "No more patriarchy issue" - Porn debate continued, Exterior decorating A social anarchist and anti-authoritarian quarterly publication.

core   +1 more source

PCNA activates the MutLγ endonuclease to promote meiotic crossing over. [PDF]

Nature, 2020
Kulkarni DS, Owens SN, Honda M, Ito M, Yang Y, Corrigan MW, Chen L, Quan AL, Hunter N.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source