Results 1 to 10 of about 34,456 (153)
FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading [PDF]
Nature CommunicationsDuring meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1 are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by homologous recombination (HR).
Akbar Zainu +11 more
doaj +2 more sources
Biomolecules, 2022 Meiotic recombination is a pivotal event that ensures faithful chromosome segregation and creates genetic diversity in gametes. Meiotic recombination is initiated by programmed double-strand breaks (DSBs), which are catalyzed by the conserved Spo11 ...
Kouji Hirota
doaj +1 more source
RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis.
PLoS Genetics, 2021 An essential component of the homologous recombination machinery in eukaryotes, the RAD54 protein is a member of the SWI2/SNF2 family of helicases with dsDNA-dependent ATPase, DNA translocase, DNA supercoiling and chromatin remodelling activities.
Miguel Hernandez Sanchez-Rebato +4 more
doaj +1 more source
Evolution of the recombination regulator PRDM9 in minke whales
BMC Genomics, 2022 Background PRDM9 is a key regulator of meiotic recombination in most metazoans, responsible for reshuffling parental genomes. During meiosis, the PRDM9 protein recognizes and binds specific target motifs via its array of C2H2 zinc-fingers encoded by a ...
Elena Damm +3 more
doaj +1 more source
Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination. [PDF]
PLoS Genetics, 2017 Meiotic recombination is required for proper homologous chromosome segregation in plants and other eukaryotes. The eukaryotic RAD51 gene family has seven ancient paralogs with important roles in mitotic and meiotic recombination.
Hang Su +6 more
doaj +1 more source
The CAF-1 and Hir Histone Chaperones Associate with Sites of Meiotic Double-Strand Breaks in Budding Yeast. [PDF]
PLoS ONE, 2015 In the meiotic prophase, programmed DNA double-strand breaks (DSB) are introduced along chromosomes to promote homolog pairing and recombination. Although meiotic DSBs usually occur in nucleosome-depleted, accessible regions of chromatin, their repair by
Elsa Brachet +3 more
doaj +1 more source
Hybrid Sterility Locus on Chromosome X Controls Meiotic Recombination Rate in Mouse. [PDF]
PLoS Genetics, 2016 Meiotic recombination safeguards proper segregation of homologous chromosomes into gametes, affects genetic variation within species, and contributes to meiotic chromosome recognition, pairing and synapsis.
Maria Balcova +10 more
doaj +1 more source
Identification and Expression of TOP3α in Gerbera hybrida
Horticultural Plant Journal, 2021 Meiotic recombination and the resulting novel allele combinations are fundamental to plant breeding and the identification of superior hybrids. However, the rate of meiotic crossovers is naturally suppressed below its potential ability, which prevents ...
Shenchong Li +5 more
doaj +1 more source
Cell & Bioscience, 2023 Background Meiotic recombination is initiated by Spo11-dependent programmed DNA double-strand breaks (DSBs) that are preferentially concentrated within genomic regions called hotspots; however, the factor(s) that specify the positions of meiotic DSB ...
Chao Liu +13 more
doaj +1 more source
Frontiers in Plant Science, 2020 Meiotic recombination ensures accurate homologous chromosome segregation during meiosis and generates novel allelic combinations among gametes. During meiosis, DNA double strand breaks (DSBs) are generated to facilitate recombination.
Yuan Yao +7 more
doaj +1 more source