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The molecular machinery of meiotic recombination. [PDF]
Biochem Soc TransMeiotic recombination, a cornerstone of eukaryotic diversity and individual genetic identity, is essential for the creation of physical linkages between homologous chromosomes, facilitating their faithful segregation during meiosis I. This process requires that germ cells generate controlled DNA lesions within their own genome that are subsequently ...
Chen L, Weir JR.
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Meiotic and Mitotic Recombination in Meiosis [PDF]
Genetics, 2013 Abstract Meiotic crossovers facilitate the segregation of homologous chromosomes and increase genetic diversity. The formation of meiotic crossovers was previously posited to occur via two pathways, with the relative use of each pathway varying between organisms; however, this paradigm could not explain all crossovers, and many of the ...
Kathryn P, Kohl, Jeff, Sekelsky
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Cilia regulate meiotic recombination in zebrafish. [PDF]
J Mol Cell Biol, 2022 Abstract Meiosis is essential for evolution and genetic diversity in almost all sexual eukaryotic organisms. The mechanisms of meiotic recombination, such as synapsis, have been extensively investigated. However, it is still unclear whether signals from the cytoplasm or even outside of the cell can regulate the meiosis process.
Xie H +8 more
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Pioneering meiotic recombination [PDF]
Genes & Development, 2020 To induce cell type-specific forms of gene regulation, pioneer factors open tightly packed, inaccessible chromatin sites, enabling the molecular machinery to act on functionally significant information encoded in DNA. While previous studies of pioneer factors have revealed their functions in transcriptional regulation, pioneer factors that open ...
Alavattam, Kris G +2 more
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Biomolecules, 2022 Meiotic recombination is a pivotal event that ensures faithful chromosome segregation and creates genetic diversity in gametes. Meiotic recombination is initiated by programmed double-strand breaks (DSBs), which are catalyzed by the conserved Spo11 ...
Kouji Hirota
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RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis.
PLoS Genetics, 2021 An essential component of the homologous recombination machinery in eukaryotes, the RAD54 protein is a member of the SWI2/SNF2 family of helicases with dsDNA-dependent ATPase, DNA translocase, DNA supercoiling and chromatin remodelling activities.
Miguel Hernandez Sanchez-Rebato +4 more
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Evolution of the recombination regulator PRDM9 in minke whales
BMC Genomics, 2022 Background PRDM9 is a key regulator of meiotic recombination in most metazoans, responsible for reshuffling parental genomes. During meiosis, the PRDM9 protein recognizes and binds specific target motifs via its array of C2H2 zinc-fingers encoded by a ...
Elena Damm +3 more
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Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination. [PDF]
PLoS Genetics, 2017 Meiotic recombination is required for proper homologous chromosome segregation in plants and other eukaryotes. The eukaryotic RAD51 gene family has seven ancient paralogs with important roles in mitotic and meiotic recombination.
Hang Su +6 more
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The CAF-1 and Hir Histone Chaperones Associate with Sites of Meiotic Double-Strand Breaks in Budding Yeast. [PDF]
PLoS ONE, 2015 In the meiotic prophase, programmed DNA double-strand breaks (DSB) are introduced along chromosomes to promote homolog pairing and recombination. Although meiotic DSBs usually occur in nucleosome-depleted, accessible regions of chromatin, their repair by
Elsa Brachet +3 more
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The Impressionistic Landscape of Meiotic Recombination [PDF]
Cell, 2011 Two high-resolution maps of meiotic recombination initiation sites across the genomes of budding yeast and mice illuminate broad similarities in the control of meiotic recombination in these diverse species but also highlight key differences. These studies offer new insights into the relationships between recombination, chromosome structure, and genome
Lichten, M., de Massy, Bernard
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