Results 11 to 20 of about 247,794 (231)

Pioneering meiotic recombination [PDF]

Genes & Development, 2020
To induce cell type-specific forms of gene regulation, pioneer factors open tightly packed, inaccessible chromatin sites, enabling the molecular machinery to act on functionally significant information encoded in DNA. While previous studies of pioneer factors have revealed their functions in transcriptional regulation, pioneer factors that open ...
Alavattam, Kris G, Abe, Hironori, Namekawa, Satoshi H   +2 more
openaire   +6 more sources

Meiotic Recombination: The Essence of Heredity [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
The study of homologous recombination has its historical roots in meiosis. In this context, recombination occurs as a programmed event that culminates in the formation of crossovers, which are essential for accurate chromosome segregation and create new combinations of parental alleles.
Hunter, Neil
openaire   +7 more sources

Probing Meiotic Recombination Decisions [PDF]

Developmental Cell, 2008
Meiotic recombination promotes genetic variation by mixing parental alleles. Two recent studies, one in this issue of Developmental Cell, have applied microarray-based methods that allow analysis of nearly all of the recombination events occurring in a single meiosis.
Roig, Ignasi, Keeney, Scott
openaire   +4 more sources

Use of a unique reporter cassette to examine 5´ to 3´ resection at a site specific DNA double-strand break during meiosis [PDF]

, 2006
Meiotic recombination in Saccharomyces cerevisiae is initiated by the formation of DNA double strand breaks (DSBs), which are created by Spoil protein.
Bishop-Bailey, Anna
core   +6 more sources

The Impressionistic Landscape of Meiotic Recombination [PDF]

Cell, 2011
Two high-resolution maps of meiotic recombination initiation sites across the genomes of budding yeast and mice illuminate broad similarities in the control of meiotic recombination in these diverse species but also highlight key differences. These studies offer new insights into the relationships between recombination, chromosome structure, and genome
Lichten, M., de Massy, Bernard
openaire   +3 more sources

Targeted Stimulation of Meiotic Recombination [PDF]

Cell, 2002
Meiotic recombination in Saccharomyces cerevisiae is initiated by programmed DNA double-strand breaks (DSBs), a process that requires the Spo11 protein. DSBs usually occur in intergenic regions that display open chromatin accessibility, but other determinants that control their frequencies and non-random chromosomal distribution remain obscure.
Pecina, A., Smith, K.N., Mezard, Christine, Murakami, Hitoshi, Ohta, K., Nicolas, A.   +5 more
openaire   +3 more sources

Hotspots for Initiation of Meiotic Recombination [PDF]

Frontiers in Genetics, 2018
Homologous chromosomes must pair and recombine to ensure faithful chromosome segregation during meiosis, a specialized type of cell division that occurs in sexually reproducing eukaryotes. Meiotic recombination initiates by programmed induction of DNA double-strand breaks (DSBs) by the conserved type II topoisomerase-like enzyme SPO11.
Tock, Andrew J, Henderson, Ian R
openaire   +5 more sources

sequenceLDhot: Detecting Recombination Hotspots. [PDF]

, 2006
Motivation: There is much local variation in recombination rates across the human genome—with the majority of recombination occuring in recombination hotspots—short regions of around ~2 kb in length that have much higher recombination rates than ...
Fearnhead, Paul
core   +4 more sources

Sex without crossing over in the yeast Saccharomycodes ludwigii

Genome Biology, 2021
Background Intermixing of genomes through meiotic reassortment and recombination of homologous chromosomes is a unifying theme of sexual reproduction in eukaryotic organisms and is considered crucial for their adaptive evolution.
Ioannis A. Papaioannou, Fabien Dutreux, France A. Peltier, Hiromi Maekawa, Nicolas Delhomme, Amit Bardhan, Anne Friedrich, Joseph Schacherer, Michael Knop   +8 more
doaj   +1 more source

Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions [PDF]

, 2013
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
Philip W. Jordan (265255), Copsey A., Prakash Arumugam, Sonya Newcombe (502072), Jordan, Philip W., Gray S., Alice Copsey (4460686), Alex D Herbert, Eva Hoffmann (159398), Li, Zhaobo, Shangming Tang, Zhaobo Li, Stephen Gray, Newnham, Louise, Herbert A.D., Chan, Andrew Chi-ho, Hannah G. Blitzblau (159462), Blitzblau, Hannah G., Gray, Stephen, Alex Herbert (725932), Hannah G Blitzblau, Hannah Blitzblau (5185454), Newcombe S., Tang, Shangming, Stephen Gray (3278418), Newnham L., Li Z., Hunter, Neil, Andrew Chi-ho Chan (3278421), Hochwagen, Andreas, Arumugam, Prakash, Shangming Tang (502071), Hochwagen A., Alice Copsey, Alice Copsey (502070), Copsey, Alice, Herbert, Alex D., Hoffmann E., Blitzblau H.G., Andreas Hochwagen (159466), Arumugam P., Louise Newnham, Neil Hunter, Philip W Jordan (16188074), Jordan P.W., Alex D. Herbert (502074), Philip W Jordan, Andrew Chi-Ho Chan, Louise Newnham (430862), Sonya Newcombe, Chan, Andrew Chi ho, Tang S., Prakash Arumugam (303310), Eva Hoffmann, Newcombe, Sonya, Andreas Hochwagen, Hunter N., Chan A.C.-h., Neil Hunter (155061), Steve Gray (5950955), Zhaobo Li (502073), Hoffmann, Eva   +61 more
core   +1 more source