Results 11 to 20 of about 61,553 (233)

Pioneering meiotic recombination [PDF]

Genes & Development, 2020
To induce cell type-specific forms of gene regulation, pioneer factors open tightly packed, inaccessible chromatin sites, enabling the molecular machinery to act on functionally significant information encoded in DNA. While previous studies of pioneer factors have revealed their functions in transcriptional regulation, pioneer factors that open ...
Alavattam, Kris G, Abe, Hironori, Namekawa, Satoshi H   +2 more
openaire   +4 more sources

The Impressionistic Landscape of Meiotic Recombination [PDF]

Cell, 2011
Two high-resolution maps of meiotic recombination initiation sites across the genomes of budding yeast and mice illuminate broad similarities in the control of meiotic recombination in these diverse species but also highlight key differences. These studies offer new insights into the relationships between recombination, chromosome structure, and genome
Lichten, M., de Massy, Bernard
openaire   +3 more sources

Hybrid Sterility Locus on Chromosome X Controls Meiotic Recombination Rate in Mouse. [PDF]

PLoS Genetics, 2016
Meiotic recombination safeguards proper segregation of homologous chromosomes into gametes, affects genetic variation within species, and contributes to meiotic chromosome recognition, pairing and synapsis.
Maria Balcova, Barbora Faltusova, Vaclav Gergelits, Tanmoy Bhattacharyya, Ondrej Mihola, Zdenek Trachtulec, Corinna Knopf, Vladana Fotopulosova, Irena Chvatalova, Sona Gregorova, Jiri Forejt   +10 more
doaj   +1 more source

Identification and Expression of TOP3α in Gerbera hybrida

Horticultural Plant Journal, 2021
Meiotic recombination and the resulting novel allele combinations are fundamental to plant breeding and the identification of superior hybrids. However, the rate of meiotic crossovers is naturally suppressed below its potential ability, which prevents ...
Shenchong Li, Ying Cheng, Dan Sun, Lulin Ma, Mingyang Li, Fan Li   +5 more
doaj   +1 more source

The molecular machinery of meiotic recombination. [PDF]

Biochem Soc Trans
Meiotic recombination, a cornerstone of eukaryotic diversity and individual genetic identity, is essential for the creation of physical linkages between homologous chromosomes, facilitating their faithful segregation during meiosis I. This process requires that germ cells generate controlled DNA lesions within their own genome that are subsequently ...
Chen L, Weir JR.
europepmc   +3 more sources

Hotspots for Initiation of Meiotic Recombination [PDF]

Frontiers in Genetics, 2018
Homologous chromosomes must pair and recombine to ensure faithful chromosome segregation during meiosis, a specialized type of cell division that occurs in sexually reproducing eukaryotes. Meiotic recombination initiates by programmed induction of DNA double-strand breaks (DSBs) by the conserved type II topoisomerase-like enzyme SPO11.
Tock, Andrew J, Henderson, Ian R
openaire   +4 more sources

Direct and indirect control of the initiation of meiotic recombination by DNA damage checkpoint mechanisms in budding yeast [PDF]

, 2013
Meiotic recombination plays an essential role in the proper segregation of chromosomes at meiosis I in many sexually reproducing organisms. Meiotic recombination is initiated by the scheduled formation of genome-wide DNA double-strand breaks (DSBs).
AJ MacQueen, AL Goldstein, BH Lee, Bilge Argunhan, C Buhler, CY Bonilla, E Martini, EF Joyce, G Vader, H Sasanuma, H Sun, H Toyoizumi, H Tsubouchi, H-C Ho, H-Y Wu, HG Blitzblau, Hideo Tsubouchi, Hiroshi Toyoizumi, J Lange, JC Harrison, JE Haber, JL Gerton, KA Henderson, KS Tung, L Wan, L Xu, L Zou, M Lichten, M Lisby, M Petronczki, Michael Lichten, MJ Neale, Neil Humphryes, S Chu, S Farmer, S Farmer, S Keeney, Sarah Farmer, Tomomi Tsubouchi, Wing-Kit Leung, Yaroslav Terentyev   +40 more
core   +12 more sources

Dual roles of R-loops in the formation and processing of programmed DNA double-strand breaks during meiosis

Cell & Bioscience, 2023
Background Meiotic recombination is initiated by Spo11-dependent programmed DNA double-strand breaks (DSBs) that are preferentially concentrated within genomic regions called hotspots; however, the factor(s) that specify the positions of meiotic DSB ...
Chao Liu, Wei Xu, Liying Wang, Zhuo Yang, Kuan Li, Jun Hu, Yinghong Chen, Ruidan Zhang, Sai Xiao, Wenwen Liu, Huafang Wei, Jia-Yu Chen, Qianwen Sun, Wei Li   +13 more
doaj   +1 more source

Targeted Stimulation of Meiotic Recombination [PDF]

Cell, 2002
Meiotic recombination in Saccharomyces cerevisiae is initiated by programmed DNA double-strand breaks (DSBs), a process that requires the Spo11 protein. DSBs usually occur in intergenic regions that display open chromatin accessibility, but other determinants that control their frequencies and non-random chromosomal distribution remain obscure.
Pecina, A., Smith, K.N., Mezard, Christine, Murakami, Hitoshi, Ohta, K., Nicolas, A.   +5 more
openaire   +3 more sources

ATM Promotes RAD51-Mediated Meiotic DSB Repair by Inter-Sister-Chromatid Recombination in Arabidopsis

Frontiers in Plant Science, 2020
Meiotic recombination ensures accurate homologous chromosome segregation during meiosis and generates novel allelic combinations among gametes. During meiosis, DNA double strand breaks (DSBs) are generated to facilitate recombination.
Yuan Yao, Xiaojing Li, Wanli Chen, Hui Liu, Limin Mi, Ding Ren, Aowei Mo, Pingli Lu   +7 more
doaj   +1 more source