Results 1 to 10 of about 54,943 (215)
DNA double-strand break repair [PDF]
Current Biology, 1999 In yeast, the genes that encode Ku70 and Ku80 are essential to maintain the length of the telomeres — the specialized chromatin structures at the ends of chromosomes. Yeast Ku might act at the telomeres by protecting the DNA end from degradation and by clustering telomeres together at the nuclear periphery.
Featherstone, Carol, Jackson, Stephen P
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DNA Double-Strand Breaks [PDF]
The Journal of Experimental Medicine, 2002 The activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) and class-switch recombination (CSR) of immunoglobulin (Ig) genes, both of which are associated with DNA double-strand breaks (DSBs). As AID is capable of deaminating deoxy-cytidine (dC) to deoxy-uracil (dU), it might induce nicks (single strand DNA breaks) and ...
Linda Bross +4 more
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High salt and DNA double-strand breaks [PDF]
Proceedings of the National Academy of Sciences, 2011 High-salt environments are often toxic to mammalian cells; however, some types, such as murine inner medullary collecting duct cells, are normally exposed to high-salt media. The IMCD3 cell line, derived from this mouse kidney cell type, is able to survive and even proliferate under high-salt conditions after a short period of adaptation (1 ...
Christophe E, Redon, William M, Bonner
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The ubiquitin landscape at DNA double-strand breaks [PDF]
Journal of Cell Biology, 2009 The intimate relationship between DNA double-strand break (DSB) repair and cancer susceptibility has sparked profound interest in how transactions on DNA and chromatin surrounding DNA damage influence genome integrity. Recent evidence implicates a substantial commitment of the cellular DNA damage response machinery to the synthesis, recognition, and ...
Messick, Troy E., Greenberg, Roger A.
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Boon and Bane of DNA Double-Strand Breaks [PDF]
International Journal of Molecular Sciences, 2021 DNA double-strand breaks (DSBs), interrupting the genetic information, are elicited by various environmental and endogenous factors. They bear the risk of cell lethality and, if mis-repaired, of deleterious mutation. This negative impact is contrasted by several evolutionary achievements for DSB processing that help maintaining stable inheritance ...
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Repair of DNA Double-Strand Breaks in Heterochromatin [PDF]
Biomolecules, 2016 DNA double-strand breaks (DSBs) are among the most damaging lesions in DNA, since, if not identified and repaired, they can lead to insertions, deletions or chromosomal rearrangements. DSBs can be in the form of simple or complex breaks, and may be repaired by one of a number of processes, the nature of which depends on the complexity of the break or ...
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SIRT6 is a DNA Double-Strand Break Sensor
eLife, 2019 Abstract DNA double strand breaks are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure, with high affinity for double strand breaks. It relocates to sites of damage independently of signalling and known sensors and activates downstream signalling ...
Onn, Lior +11 more
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Chromatin Remodeling at DNA Double-Strand Breaks [PDF]
Cell, 2013 DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to ionizing radiation. The repair of DSBs involves both posttranslational modification of nucleosomes and concentration of DNA-repair proteins at the site of damage. Consequently, nucleosome packing and chromatin architecture surrounding the DSB may limit the ability of
Price, Brendan D., D’Andrea, Alan D.
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DNA double-strand break repair and development [PDF]
Oncogene, 2007 Normal development of an organism requires the ability to respond to DNA damage. A particularly deleterious lesion is a DNA double-strand break (DSB). The cellular response to DNA DSBs occurs via an integrated sensing and signaling network that maintains genomic stability.
E R, Phillips, P J, McKinnon
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Physiological Roles of DNA Double-Strand Breaks [PDF]
Journal of Nucleic Acids, 2017 Genomic integrity is constantly threatened by sources of DNA damage, internal and external alike. Among the most cytotoxic lesions is the DNA double-strand break (DSB) which arises from the cleavage of both strands of the double helix. Cells boast a considerable set of defences to both prevent and repair these breaks and drugs which derail these ...
Khan, Farhaan A, Ali, Syed O
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