Results 1 to 10 of about 104,786 (306)
In vivo base editing of post-mitotic sensory cells
Nature Communications, 2018 Base editing allows the precise introduction of point mutations into cellular DNA without requiring double-stranded DNA breaks or homology-directed repair, which is inefficient in postmitotic cells.
Wei-Hsi Yeh +4 more
doaj +1 more source
BMN673 sensitizes rhabdomyosarcoma tumors to irradiation in vivo [PDF]
, 2020 Bone and soft tissue sarcomas are mesenchymal tumors that occur rarely in adults, representing only 1% of total malignancies, but comprise up to 13% of malignant tumors in children.1 Rhabdomyosarcoma, a soft tissue sarcoma that commonly affects children,
Jacob, Connor
core
Targeting ATM pathway for therapeutic intervention in cancer [PDF]
, 2012 The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Chakarov, Stoyan +4 more
core +3 more sources
Checkpoint Responses to DNA Double-Strand Breaks
Annual Review of Biochemistry, 2020 Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired or cancers if improperly repaired. In response to DNA DSBs, cells activate a complex DNA damage checkpoint (DDC) response that arrests the cell cycle, reprograms gene expression,
David P, Waterman +2 more
openaire +3 more sources
MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis
Nature Communications, 2016 MEF2C is a transcription factor required for B-cell proliferation. Here the authors show that MEF2C is also needed in B-cell development and recovery from stress by inducing expression of DNA repair factors that prevent double stranded breaks and enable ...
Wenyuan Wang +11 more
doaj +1 more source
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA [PDF]
, 2012 Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5'-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions requires ...
Austin, Caroline +10 more
core +3 more sources
Multiple sgRNAs with overlapping sequences enhance CRISPR/Cas9-mediated knock-in efficiency
Experimental and Molecular Medicine, 2018 Genome editing: Improving efficiency by improving DNA repair A method to improve the efficiency of repairing double-stranded DNA breaks facilitates the production of animals with edited genomes.
Da Eun Jang +11 more
doaj +1 more source
DNA intercalation and cleavage of an antitumor antibiotic dynemicin that contains anthracycline and enediyne cores [PDF]
, 1990 Dynemicin is a hybrid containing anthraquinone and enediyne cores, which contribute to binding and cleavage of DNA, respectively. DNA strand scission by the antitumor antibiotic is significantly enhanced by the addition of NADPH or thiol compounds.
Konishi, Masataka +3 more
core +1 more source
DNA Double Strand Break Repair: A Radiation Perspective [PDF]
Antioxidants & Redox Signaling, 2013 Ionizing radiation (IR) can induce a wide range of unique deoxyribonucleic acid (DNA) lesions due to the spatiotemporal correlation of the ionization produced. Of these, DNA double strand breaks (DSBs) play a key role. Complex mechanisms and sophisticated pathways are available within cells to restore the integrity and sequence of the damaged DNA ...
Kavanagh, Joy N. +3 more
openaire +4 more sources
Quantification of
Medical Physics, 2018 PurposeThis study aims to standardize the simulation procedure in measuring DNA double‐strand breaks (DSBs), by using advanced Monte Carlo toolkits, and newly introduced experimental methods for DNA DSB measurement.MethodsFor the experimental quantification of DNA DSB, an innovative DNA dosimeter was used to produce experimental data.
Chatzipapas, Konstantinos P. +7 more
openaire +2 more sources