Results 41 to 50 of about 104,786 (306)
Nature Communications, 2016 Double stranded DNA breaks are generated during rearrangements of lymphocyte antigen receptors. Here the authors show that the DNA breaks induce phosphorylation of nuclear GSK3β at Ser389/Thr390, protecting the activated lymphocytes from necroptosis ...
Tina M. Thornton +12 more
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Frontiers in Oncology, 2022 Radiation therapy induces double-stranded DNA breaks in tumor cells, which leads to their death. A fraction of glioblastoma cells repair such breaks and reinitiate tumor growth.
Galina Pavlova +13 more
doaj +1 more source
hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity [PDF]
, 2013 hSSB1 is a recently discovered single-stranded DNA binding protein that is essential for efficient repair of DNA double-strand breaks (DSBs) by the homologous recombination pathway.
Bain, Amanda +7 more
core +1 more source
High salt and DNA double-strand breaks [PDF]
Proceedings of the National Academy of Sciences, 2011 High-salt environments are often toxic to mammalian cells; however, some types, such as murine inner medullary collecting duct cells, are normally exposed to high-salt media. The IMCD3 cell line, derived from this mouse kidney cell type, is able to survive and even proliferate under high-salt conditions after a short period of adaptation (1 ...
Christophe E, Redon, William M, Bonner
openaire +2 more sources
PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
Nature Communications, 2017 Non-homologous end-joining is the key pathway for repairing double-stranded DNA breaks in mammalian cells. Here the authors show that PAXX promotes the accumulation of KU at DNA breaks and is essential for end-joining in cells lacking XLF.
Xiangyu Liu +4 more
doaj +1 more source
Sliding to the rescue of damaged DNA
eLife, 2012 Single-molecule imaging experiments have shed new light on the methods used by the enzyme RecA to align single- and double-stranded DNA so that double-strand breaks can be repaired.
Bryan Gibb, Eric C Greene
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Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling
Nature Communications, 2021 The RNA-sensing pathway has been associated with type I interferon (IFN) production induced by DNA damaging agents. Here the authors reveal that RIG-I, a cytosolic RNA sensor that recognizes RNA virus and initiates IFN signaling, is recruited to double ...
Guijie Guo +19 more
doaj +1 more source
A moonlighting metabolic protein influences repair at DNA double-stranded breaks. [PDF]
, 2015 Catalytically active proteins with divergent dual functions are often described as 'moonlighting'. In this work we characterize a new, chromatin-based function of Lys20, a moonlighting protein that is well known for its role in metabolism.
Aris, John P +2 more
core +1 more source
Nucleolar responses to DNA double-strand breaks [PDF]
Nucleic Acids Research, 2015 Maintenance of cellular homeostasis is key to prevent transformation and disease. The cellular response to DNA double-strand breaks, primarily orchestrated by the ATM/ATR kinases is one of many mechanisms that serve to uphold genome stability and homeostasis.
Dorthe Helena Larsen, Manuel Stucki
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Reprogramming the mechanism of action of chlorambucil by coupling to a G-quadruplex ligand. [PDF]
, 2014 The nitrogen mustard Chlorambucil (Chl) generates covalent adducts with double-helical DNA and inhibits cell proliferation. Among these adducts, interstrand cross-links (ICLs) are the most toxic, as they stall replication by generating DNA double strand ...
Balasubramanian, Shankar +2 more
core +3 more sources