Results 1 to 10 of about 55,108 (306)

Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila.

PLoS Genetics, 2010
DNA double-strand breaks are repaired by multiple mechanisms that are roughly grouped into the categories of homology-directed repair and non-homologous end joining.
Sze Ham Chan, Amy Marie Yu, Mitch McVey
doaj   +3 more sources

Nonhomologous end-joining uses distinct mechanisms to repair each strand of a double strand break [PDF]

Nature Communications
Nonhomologous end-joining repairs chromosomal double strand breaks, but it is unknown whether both strands are repaired by this pathway, and if one strand break’s repair path impacts the other. Here, we show that nonhomologous end-joining employs both of
Adam J. Luthman, Kishore K. Chiruvella, Andrea M. Kaminski, Thomas A. Kunkel, Lars C. Pedersen, Dale A. Ramsden   +5 more
doaj   +2 more sources

Progress of research on double-strand break damage induced by heavy-ion beam radiation and repair mechanism

Fushe yanjiu yu fushe gongyi xuebao, 2023
Heavy-ion beam radiation can cause cell DNA double-strand breaks (DSBs), which are factors that lead to genomic instability. Existing studies have demonstrated that homologous end joining, homologous recombination, single-strand annealing, and selective ...
REN Junle, GUO Xiaopeng, LEI Cairong, ZHANG Miaomiao, CHAI Ran, LU Dong   +5 more
doaj   +1 more source

CRISPR-based gene editing of non-homologous end joining factors biases DNA repair pathway choice toward single-strand annealing in Aedes aegypti

Current Research in Biotechnology, 2023
To maintain genome stability, eukaryotic cells orchestrate DNA repair pathways to process DNA double-strand breaks (DSBs) that result from diverse developmental or environmental stimuli. Bias in the selection of DSB repair pathways, either non-homologous
Keun Chae, Justin M. Overcash, Chanell Dawson, Collin Valentin, Hitoshi Tsujimoto, Kevin M. Myles, Zach N. Adelman   +6 more
doaj   +1 more source

Essential factors for incompatible DNA end joining at chromosomal DNA double strand breaks in vivo. [PDF]

PLoS ONE, 2011
Non-homologous end joining (NHEJ) is a major pathway for the repair of DNA double strand break (DSBs) with incompatible DNA ends, which are often generated by ionizing irradiation.
Hideaki Ogiwara, Takashi Kohno
doaj   +1 more source

Turning end-joining upside down in mitosis

Molecular & Cellular Oncology, 2021
How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions.
Marta Llorens-Agost, Michael Ensminger, Hang Phuong Le, Wolf-Dietrich Heyer, Markus Löbrich   +4 more
doaj   +1 more source

Alternative end-joining mechanisms: a historical perspective

Frontiers in Genetics, 2013
In the presence of functional DNA repair pathways, DNA double-strand breaks (DSBs) are mainly repaired by non-homologous end-joining (NHEJ) or homologous recombination (HR), two conserved pathways that protect cells from aberrant chromosomal ...
Anabelle eDecottignies
doaj   +1 more source

Mechanistic and genetic basis of single-strand templated repair at Cas12a-induced DNA breaks in Chlamydomonas reinhardtii

Nature Communications, 2021
Single-stranded oligodeoxynucleotides are often used as templates for DNA repair during genome editing. Here the authors show that, unlike in animals, single-strand templated DNA repair in Chlamydomonas reinhardtii relies on the alternative end-joining ...
Aron Ferenczi, Yen Peng Chew, Erika Kroll, Charlotte von Koppenfels, Andrew Hudson, Attila Molnar   +5 more
doaj   +1 more source

Linking DNA repair and cell cycle progression through serine ADP-ribosylation of histones

Nature Communications, 2022
Poly(ADP-ribose)-polymerases (PARPs) are a cornerstone of the DNA damage response that promote DNA repair by modifying target proteins with ADP-ribose.
Julien Brustel, Tetsuya Muramoto, Kazuki Fumimoto, Jessica Ellins, Catherine J. Pears, Nicholas D. Lakin   +5 more
doaj   +1 more source

Determination of the DNA repair pathways utilised by acute lymphoblastic leukaemia cells following daunorubicin treatment

BMC Research Notes, 2019
Objective DNA double strand breaks (DNA-DSBs) are among the most lethal DNA lesions leading to genomic instability and repaired by either homologous recombination (HR) or the non-homologous end joining (NHEJ) mechanisms.
Hussain Mubarak Al-Aamri, Helen R. Irving, Terri Meehan-Andrews, Christopher Bradley   +3 more
doaj   +1 more source