Results 11 to 20 of about 55,108 (306)

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining

Cell Reports, 2015
Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non-homologous end-joining (cNHEJ).
Cook, R, Zoumpoulidou, G, Luczynski, MT, Rieger, S, Moquet, J, Spanswick, VJ, Hartley, JA, Rothkamm, K, Huang, PH, Mittnacht, S   +9 more
openaire   +6 more sources

Polθ promotes the repair of 5′-DNA-protein crosslinks by microhomology-mediated end-joining

Cell Reports, 2021
Summary: DNA polymerase θ (Polθ) confers resistance to chemotherapy agents that cause DNA-protein crosslinks (DPCs) at double-strand breaks (DSBs), such as topoisomerase inhibitors. This suggests Polθ might facilitate DPC repair by microhomology-mediated
Gurushankar Chandramouly, Shuren Liao, Timur Rusanov, Nikita Borisonnik, Marissa L. Calbert, Tatiana Kent, Katherine Sullivan-Reed, Umeshkumar Vekariya, Ekaterina Kashkina, Tomasz Skorski, Hong Yan, Richard T. Pomerantz   +11 more
doaj   +4 more sources

Nonhomologous DNA end-joining for repair of DNA double-strand breaks [PDF]

Journal of Biological Chemistry, 2018
Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand break (DSB) repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of the S and G2 phases. NHEJ relies on Ku to thread onto DNA termini and thereby improve the affinity of the NHEJ enzymatic components consisting of polymerases (Pol μ and Pol λ), a ...
Pannunzio, Nicholas, Watanabe, Go, Lieber, Michael   +2 more
openaire   +4 more sources

Double‐strand break repair mediated by DNA end‐joining [PDF]

Genes to Cells, 1998
DNA double‐strand breaks formed by ionizing irradiation or other stresses are repaired by homologous recombination or DNA end‐joining. This review focuses on the mechanism of double‐strand break repair mediated by DNA end‐joining, in which many factors have recently been identified.
Y, Tsukamoto, H, Ikeda
openaire   +2 more sources

Meiotic DNA Repair in the Nucleolus Employs a Nonhomologous End-Joining Mechanism [PDF]

The Plant Cell, 2019
Abstract Ribosomal RNA genes are arranged in large arrays with hundreds of rDNA units in tandem. These highly repetitive DNA elements pose a risk to genome stability since they can undergo non-allelic exchanges. During meiosis DNA double strand breaks (DSBs) are induced as part of the regular program to generate gametes.
Jason Sims, Gregory P. Copenhaver, Peter Schlögelhofer   +2 more
openaire   +3 more sources

Crystal structure of the Xrcc4 DNA repair protein and implications for end joining [PDF]

The EMBO Journal, 2000
XRCC4 is essential for carrying out non-homologous DNA end joining (NHEJ) in all eukaryotes and, in particular, V(D)J recombination in vertebrates. Xrcc4 protein forms a complex with DNA ligase IV that rejoins two DNA ends in the last step of V(D)J recombination and NHEJ to repair double strand breaks.
Junop, MS, Modesti, M (Mauro), Guarné, A, Ghirlando, R, Gellert, M, Yang, W   +5 more
openaire   +3 more sources

ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining [PDF]

Oncogene, 2019
Abstract Efficient repair of DNA double-strand breaks (DSBs) is of critical importance for cell survival. Although non-homologous end joining (NHEJ) is the most used DSBs repair pathway in the cells, how NHEJ factors are sequentially recruited to damaged chromatin remains unclear.
Nicolai, Sara, Mahen, Robert, Raschellà, Giuseppe, Marini, Alberto, Pieraccioli, Marco, Malewicz, Michal, Venkitaraman, Ashok R., Melino, Gerry   +7 more
openaire   +4 more sources

SAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining [PDF]

Nucleic Acids Research, 2021
Abstract Aberrant end joining of DNA double strand breaks leads to chromosomal rearrangements and to insertion of nuclear or mitochondrial DNA into breakpoints, which is commonly observed in cancer cells and constitutes a major threat to genome integrity. However, the mechanisms that are causative for these insertions are largely unknown.
Ekaterina Akimova, Franz Josef Gassner, Maria Schubert, Stefan Rebhandl, Claudia Arzt, Stefanie Rauscher, Vanessa Tober, Nadja Zaborsky, Richard Greil, Roland Geisberger   +9 more
openaire   +2 more sources

Potential Role for 53BP1 in DNA End-joining Repair through Direct Interaction with DNA [PDF]

Journal of Biological Chemistry, 2003
Upon DNA damage, p53-binding protein 1 (53BP1) relocalizes to sites of DNA double-strand breaks and forms discrete nuclear foci, suggesting its role in DNA damage responses. We show that 53BP1 changed its localization from the detergent soluble to insoluble fraction after treatment of cells with x-ray, but not with ultraviolet or hydroxyurea.
Kuniyoshi, Iwabuchi, Balaka Piku, Basu, Boris, Kysela, Takayuki, Kurihara, Masao, Shibata, Deyu, Guan, Yongheng, Cao, Tomio, Hamada, Kouji, Imamura, Penny A, Jeggo, Takayasu, Date, Aidan J, Doherty   +11 more
openaire   +2 more sources

Non-homologous end joining as a mechanism of DNA repair [PDF]

Current Biology, 2001
In a field where we are still identifying the key players, it is clear that there is much left to learn about non-homologous end joining as a mechanism of DNA repair. And any process acting on DNA must be considered in the broader context of chromatin conformation and sub-nuclear structure: there is clear evidence, largely from yeast, of interactions ...
openaire   +2 more sources