Results 21 to 30 of about 55,108 (306)

Imprecision and DNA Break Repair Biased towards Incompatible End Joining in Leukemia [PDF]

Molecular Cancer Research, 2018
Abstract Cancer is a genetic disease caused by mutations and chromosomal abnormalities that contribute to uncontrolled cell growth. In addition, cancer cells can rapidly respond to conventional and targeted therapies by accumulating novel and often specific genetic lesions leading to acquired drug resistance and relapsing disease.
Gassner, Franz, Schubert, Maria, Rebhandl, Stefan, Spandl, Karina, Zaborsky, Nadja, Catakovic, Kemal, Blaimer, Stephanie, Hebenstreit, Daniel, Griel, Richard, Geisberger, Roland   +9 more
openaire   +3 more sources

REPAIRtoire--a database of DNA repair pathways. [PDF]

, 2010
REPAIRtoire is the first comprehensive database resource for systems biology of DNA damage and repair. The database collects and organizes the following types of information: (i) DNA damage linked to environmental mutagenic and cytotoxic agents, (ii ...
Rother, Kristian, K. Poleszak, Papaj, Grzegorz, E. Osinska, Bujnicki, Janusz M, Lesiak, Justyna, G. Papaj, J. Lesiak, Milanowska, Kaja, J. Krwawicz, Kosinski, Jan, K. Rother, Krwawicz, Joanna, K. Milanowska, Poleszak, Katarzyna, Osinska, Ewelina, J. Kosinski, J. M. Bujnicki   +17 more
core   +1 more source

Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms [PDF]

Nucleic Acids Research, 2015
DNA double stranded breaks (DSBs) are one of the most deleterious types of DNA lesions. The main pathways responsible for repairing these breaks in eukaryotic cells are homologous recombination (HR) and non-homologous end-joining (NHEJ). However, a third group of still poorly characterized DSB repair pathways, collectively termed microhomology-mediated
Kostyrko, K., Mermod, N.
openaire   +4 more sources

Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia [PDF]

Molecular Cell, 2010
Fanconi anemia (FA) is a complex cancer susceptibility disorder associated with DNA repair defects and infertility, yet the precise function of the FA proteins in genome maintenance remains unclear. Here we report that C. elegans FANCD2 (fcd-2) is dispensable for normal meiotic recombination but is required in crossover defective mutants to prevent ...
Adele Adamo, Spencer J Collis, Carrie A Adelman, Nicola Silva, Zuzana Horejsi, Jordan D Ward, Enrique MartinezPerez, Simon J Boulton, Adriana La Volpe   +8 more
openaire   +4 more sources

DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. [PDF]

, 2013
Antigenic variation in African trypanosomes requires monoallelic transcription and switching of variant surface glycoprotein (VSG) genes. The transcribed VSG, always flanked by '70 bp'-repeats and telomeric-repeats, is either replaced through DNA double ...
Glover, Lucy, Horn, David, Horn, David; id_orcid, Lucy Glover (24966), Sam Alsford, David Horn (24969), Alsford, Sam, Lucy Glover, Sam Alsford (24967), David Horn   +9 more
core   +1 more source

A Sir2-like protein participates in mycobacterial NHEJ. [PDF]

PLoS ONE, 2011
In eukaryotic cells, repair of DNA double-strand breaks (DSBs) by the nonhomologous end-joining (NHEJ) pathway is critical for genome stability. In contrast to the complex eukaryotic repair system, bacterial NHEJ apparatus consists of only two proteins ...
Zhongdao Li, Jikai Wen, Yaning Lin, Shihua Wang, Peng Xue, Zhiping Zhang, Ying Zhou, Xiao Wang, Li Sui, Li-Jun Bi, Xian-En Zhang   +10 more
doaj   +1 more source

Mechanistic Modelling and Bayesian Inference Elucidates the Variable Dynamics of Double-Strand Break Repair.

PLoS Computational Biology, 2016
DNA double-strand breaks are lesions that form during metabolism, DNA replication and exposure to mutagens. When a double-strand break occurs one of a number of repair mechanisms is recruited, all of which have differing propensities for mutational ...
Mae L Woods, Chris P Barnes
doaj   +1 more source

Xlf1 Is Required for DNA Repair by Nonhomologous End Joining in Schizosaccharomyces pombe [PDF]

Genetics, 2007
Abstract The accurate repair of DNA double-strand breaks is essential for cell survival and maintenance of genome integrity. Here we describe xlf1+, a gene in the fission yeast Schizosaccharomyces pombe that is required for repair of double-strand breaks by nonhomologous end joining during G1 phase of the cell cycle. Xlf1 is the ortholog
Santiago, Cavero, Charly, Chahwan, Paul, Russell   +2 more
openaire   +2 more sources

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

Cell Reports, 2016
Paralog of XRCC4 and XLF (PAXX) is a member of the XRCC4 superfamily and plays a role in nonhomologous end-joining (NHEJ), a DNA repair pathway critical for lymphocyte antigen receptor gene assembly.
Chloé Lescale, Hélène Lenden Hasse, Andrew N. Blackford, Gabriel Balmus, Joy J. Bianchi, Wei Yu, Léa Bacoccina, Angélique Jarade, Christophe Clouin, Rohan Sivapalan, Bernardo Reina-San-Martin, Stephen P. Jackson, Ludovic Deriano   +12 more
doaj   +1 more source

Repair of DNA double-strand breaks by mammalian alternative end-joining pathways [PDF]

Journal of Biological Chemistry, 2018
Alternative end-joining (a-EJ) pathways, which repair DNA double-strand breaks (DSBs), are initiated by end resection that generates 3' single strands. This reaction is shared, at least in part, with homologous recombination but distinguishes a-EJ from the major nonhomologous end-joining pathway.
Annahita, Sallmyr, Alan E, Tomkinson
openaire   +2 more sources