Results 31 to 40 of about 55,108 (306)

Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.

PLoS Genetics, 2014
Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability.
Matthew J Yousefzadeh, David W Wyatt, Kei-Ichi Takata, Yunxiang Mu, Sean C Hensley, Junya Tomida, Göran O Bylund, Sylvie Doublié, Erik Johansson, Dale A Ramsden, Kevin M McBride, Richard D Wood   +11 more
doaj   +1 more source

The Transcriptional Response to DNA-Double-Strand Breaks in Physcomitrella patens. [PDF]

PLoS ONE, 2016
The model bryophyte Physcomitrella patens is unique among plants in supporting the generation of mutant alleles by facile homologous recombination-mediated gene targeting (GT).
Yasuko Kamisugi, John W Whitaker, Andrew C Cuming   +2 more
doaj   +1 more source

DNA End Joining: G0-ing to the Core

Biomolecules, 2021
Humans have evolved a series of DNA double-strand break (DSB) repair pathways to efficiently and accurately rejoin nascently formed pairs of double-stranded DNA ends (DSEs).
Richard L. Frock, Cheyenne Sadeghi, Jodie Meng, Jing L. Wang   +3 more
doaj   +1 more source

Methods for Enhancing Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Mediated Homology-Directed Repair Efficiency

Frontiers in Genetics, 2019
The evolution of organisms has provided a variety of mechanisms to maintain the integrity of its genome, but as damage occurs, DNA damage repair pathways are necessary to resolve errors.
Xi-Dian Tang, Fei Gao, Ming-Jie Liu, Qin-Lei Fan, De-Kun Chen, Wen-Tao Ma   +5 more
doaj   +1 more source

Making Ends Meet: Repairing Breaks in Bacterial DNA by Non-Homologous End-Joining [PDF]

PLoS Genetics, 2006
DNA double-strand breaks (DSBs) are one of the most dangerous forms of DNA lesion that can result in genomic instability and cell death. Therefore cells have developed elaborate DSB-repair pathways to maintain the integrity of genomic DNA. There are two major pathways for the repair of DSBs in eukaryotes: homologous recombination and non-homologous end-
Bowater, R, Doherty, Aidan J.
openaire   +6 more sources

DNA double-strand break repair in mammals

Journal of Radiation and Cancer Research, 2017
Failure in repair of DNA double-strand breaks (DSBs) could result in various disorders in mammals including cancer. Among various exogenous agents, radiation is one of the primary causes for induction of DSBs.
Monica Pandey, Sathees C Raghavan
doaj   +1 more source

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA [PDF]

, 2012
Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5'-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions requires ...
Caroline A. Austin, Graham H. Jackson, Nicholas J. Morris, Zbyslaw Sondka, Tainer, JA, Padget, Kay, Simon J. Cockell, Curtis, H, Cockell, SJ, Curtis, Hannah, Sondka, Zbyslaw, Austin, CA, John A. Tainer, Cowell, IG, Austin, Caroline, Padget, K, Morris, Nicholas, Moiani, Davide, Cowell, Ian, Ian G. Cowell, Sondka, Z, Lee, KC, Tainer, John, Jackson, Graham, Kay Padget, Moiani, D, Lee, Ka Cheong, Jackson, GH, Ka Cheong Lee, Davide Moiani, Hannah Curtis, Morris, NJ, Cockell, Simon   +32 more
core   +1 more source

Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane

Nature Communications, 2019
Rif1 is involved in different processes such as telomere homeostasis, DNA replication timing, and DNA double strand break (DSB) repair pathway choice.
Gabriele A. Fontana, Daniel Hess, Julia K. Reinert, Stefano Mattarocci, Benoît Falquet, Dominique Klein, David Shore, Nicolas H. Thomä, Ulrich Rass   +8 more
doaj   +1 more source

The NF90/NF45 Complex Participates in DNA Break Repair via Nonhomologous End Joining [PDF]

Molecular and Cellular Biology, 2011
Nuclear factor 90 (NF90), an RNA-binding protein implicated in the regulation of gene expression, exists as a heterodimeric complex with NF45. We previously reported that depletion of the NF90/NF45 complex results in a multinucleated phenotype. Time-lapse microscopy revealed that binucleated cells arise by incomplete abscission of progeny cells ...
Raghavendra A, Shamanna, Mainul, Hoque, Anita, Lewis-Antes, Edouard I, Azzam, David, Lagunoff, Tsafi, Pe'ery, Michael B, Mathews   +6 more
openaire   +2 more sources

Akt-Mediated Phosphorylation of XLF Impairs Non-Homologous End-Joining DNA Repair [PDF]

Molecular Cell, 2015
Deficiency in repair of damaged DNA leads to genomic instability and is closely associated with tumorigenesis. Most DNA double-strand-breaks (DSBs) are repaired by two major mechanisms, homologous-recombination (HR) and non-homologous-end-joining (NHEJ). Although Akt has been reported to suppress HR, its role in NHEJ remains elusive.
Liu, Pengda, Gan, Wenjian, Guo, Chunguang, Xie, Anyong, Gao, Daming, Guo, Jianping, Zhang, Jinfang, Willis, Nicholas, Su, Arthur, Asara, John M., Scully, Ralph, Wei, Wenyi   +11 more
openaire   +2 more sources