Results 1 to 10 of about 72,928 (165)

SIRT6 is a DNA double-strand break sensor

eLife, 2020
DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure that has high affinity for DSB.
Lior Onn, Miguel Portillo, Stefan Ilic, Gal Cleitman, Daniel Stein, Shai Kaluski, Ido Shirat, Zeev Slobodnik, Monica Einav, Fabian Erdel, Barak Akabayov, Debra Toiber   +11 more
doaj   +5 more sources

TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats

Cell Reports, 2018
Summary: Trinucleotide repeat expansions involving CTG/CAG triplets are responsible for several neurodegenerative disorders, including myotonic dystrophy and Huntington’s disease. Because expansions trigger the disease, contracting repeat length could be
Valentine Mosbach, Lucie Poggi, David Viterbo, Marine Charpentier, Guy-Franck Richard   +4 more
doaj   +3 more sources

Nonhomologous end-joining uses distinct mechanisms to repair each strand of a double strand break [PDF]

Nature Communications
Nonhomologous end-joining repairs chromosomal double strand breaks, but it is unknown whether both strands are repaired by this pathway, and if one strand break’s repair path impacts the other. Here, we show that nonhomologous end-joining employs both of
Adam J. Luthman, Kishore K. Chiruvella, Andrea M. Kaminski, Thomas A. Kunkel, Lars C. Pedersen, Dale A. Ramsden   +5 more
doaj   +2 more sources

PRMT5 genetic interactions with DNA double strand break repair genes. [PDF]

PLoS ONE
Protein arginine methyltransferase 5 (PRMT5) has pleiotropic functions in human cells but also participates in orchestrating DNA double strand break (DSB) repair.
Hunter J Bliss, Juliana Tron, Wesley Bush, Renee A Bouley, Ruben C Petreaca   +4 more
doaj   +2 more sources

Study of Biological Effects of Fast Neutrons (2-14 MeV) Using Monte Carlo Method on DNA Atomic Model [PDF]

مجله علوم و فنون هسته‌ای, 2020
This study investigates the direct effect of fast neutrons with the energy ranging from 2MeV to 14MeV, and calculates the single-strand break and double-strand break on the Deoxyribon Nucleic Acid (DNA) atomic structure, using Monte Carlo method. To this
A. Zabihi, Gh. Forozani, F. Semsarha, A. Moslehi, P. Rezaeian   +4 more
doaj   +1 more source

Beta HPV Deregulates Double-Strand Break Repair

Viruses, 2022
Beta human papillomavirus (beta HPV) infections are common in adults. Certain types of beta HPVs are associated with nonmelanoma skin cancer (NMSC) in immunocompromised individuals. However, whether beta HPV infections promote NMSC in the immunocompetent
Changkun Hu, Nicholas Wallace
doaj   +1 more source

Molecular Effects of Atmospheric Pressure Plasma Jet on the Double-Stranded DNA [PDF]

Iranian Journal of Medical Physics, 2017
Introduction The aim of this study was toinvestigate the sterilization potential of atmospheric pressure plasma jet (APPJ) and interactions of this technology with double-stranded DNA using the polymerase chain reaction (PCR) and single-strand ...
Abasalt Hosseinzadeh Colagar, Seyed Mohsen Mortazavi, Vahid Arab-Yarmohammadi, Farshad Sohbatzadeh   +3 more
doaj   +1 more source

Strand asymmetry influences mismatch resolution during a single-strand annealing

Genome Biology, 2022
Background Biases of DNA repair can shape the nucleotide landscape of genomes at evolutionary timescales. The molecular mechanisms of those biases are still poorly understood because it is difficult to isolate the contributions of DNA repair from those ...
Victoria O. Pokusaeva, Aránzazu Rosado Diez, Lorena Espinar, Albert Torelló Pérez, Guillaume J. Filion   +4 more
doaj   +1 more source

Fanconi anemia associated protein 20 (FAAP20) plays an essential role in homology-directed repair of DNA double-strand breaks

Communications Biology, 2023
FAAP20 is a Fanconi anemia (FA) protein that associates with the FA core complex to promote FANCD2/FANCI monoubiquitination and activate the damage response to interstrand crosslink damage.
Anna Palovcak, Fenghua Yuan, Ramiro Verdun, Liang Luo, Yanbin Zhang   +4 more
doaj   +1 more source

Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution

Cells, 2020
Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome.
Terrence Hanscom, Mitch McVey
doaj   +1 more source