Results 11 to 20 of about 89,922 (309)
Targeting the DNA double strand break repair machinery in prostate cancer. [PDF]
PLoS ONE, 2011 Regardless of the achievable remissions with first line hormone therapy in patients with prostate cancer (CaP), the disease escapes the hormone dependent stage to a more aggressive status where chemotherapy is the only effective treatment and no ...
Fadhel S Shaheen +9 more
doaj +2 more sources
Branch migration prevents DNA loss during double-strand break repair. [PDF]
PLoS Genetics, 2014 The repair of DNA double-strand breaks must be accurate to avoid genomic rearrangements that can lead to cell death and disease. This can be accomplished by promoting homologous recombination between correctly aligned sister chromosomes.
Julia S P Mawer, David R F Leach
doaj +3 more sources
Sex and the Single (Double-Strand) Break [PDF]
Molecular Cell, 2002 It has been known for some time that DNA double-strand breaks (DSBs) initiate homologous recombination during meiosis. Two recent studies show that the fate of a single DSB in yeast is strongly influenced by the presence of other breaks in the genome, hinting that cell-wide or chromosome-regional mechanisms control the outcome of DSB repair.
Martini, Emmanuelle, Keeney, Scott
openaire +2 more sources
DNA resection at chromosome breaks promotes genome stability by constraining non-allelic homologous recombination. [PDF]
PLoS Genetics, 2012 DNA double-strand breaks impact genome stability by triggering many of the large-scale genome rearrangements associated with evolution and cancer. One of the first steps in repairing this damage is 5'→3' resection beginning at the break site.
Frederick J Tan +2 more
doaj +1 more source
DNA double-strand break repair [PDF]
Current Biology, 1999 In yeast, the genes that encode Ku70 and Ku80 are essential to maintain the length of the telomeres — the specialized chromatin structures at the ends of chromosomes. Yeast Ku might act at the telomeres by protecting the DNA end from degradation and by clustering telomeres together at the nuclear periphery.
Featherstone, Carol, Jackson, Stephen P
openaire +2 more sources
Meiotic Genes and DNA Double Strand Break Repair in Cancer
Frontiers in Genetics, 2022 Tumor cells show widespread genetic alterations that change the expression of genes driving tumor progression, including genes that maintain genomic integrity.
Lea Lingg +6 more
doaj +1 more source
Meiotic chromosome dynamics and double strand break formation in reptiles
Frontiers in Cell and Developmental Biology, 2022 During meiotic prophase I, tightly regulated processes take place, from pairing and synapsis of homologous chromosomes to recombination, which are essential for the generation of genetically variable haploid gametes.
Laia Marín-Gual +11 more
doaj +1 more source
Double-Strand Break Repair [PDF]
Journal of Biological Chemistry, 1997 DNA double-strand breaks (DSBs) are the most dangerous form of DNA damage and can lead to death, mutation, or malignant transformation. Mammalian cells use three major pathways to repair DSBs: homologous recombination (HR), classical nonhomologous end joining (C-NHEJ), and alternative end joining (A-NHEJ).
openaire +2 more sources
NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes [PDF]
, 2011 NF-κB is involved in immune responses, inflammation, oncogenesis, cell proliferation and apoptosis. Even though NF-κB can be activated by DNA damage via Ataxia telangiectasia-mutated (ATM) signalling, little was known about an involvement in DNA repair ...
Salles, Daniela +20 more
core +1 more source
Transcription, 2013 DNA lesions pose a physical obstacle to DNA-dependent cellular transactions such as replication and transcription. A great deal is known regarding RNA polymerase II (RNAP II) transcription stalling in the presence of lesions induced by UV, but recent studies have uncovered previously uncharacterized behavior of the RNAP II machinery in the presence of ...
Pankotai Tibor, Soutoglou Evi
openaire +4 more sources