Results 41 to 50 of about 89,922 (309)
Mre11-Rad50 oligomerization promotes DNA double-strand break repair
Nature Communications, 2022 The Mre11-Rad50 (MR) complex has key functions in the detection, signaling and repair of DNA breaks. Here the authors use transmission electron microscopy to show MR oligomerization is governed by a small beta-sheet protruding from the head domain of ...
Vera M. Kissling +12 more
doaj +1 more source
Frontiers in Biomedical Technologies, 2021 Purpose: The biological effects of ionizing radiation at the cellular and subcellular scales are studied by the number of breaks in the DNA molecule that provides a quantitative description of the stochastic aspects of energy deposition at cellular ...
Parvin Ahmadi +2 more
doaj +1 more source
High salt and DNA double-strand breaks [PDF]
Proceedings of the National Academy of Sciences, 2011 High-salt environments are often toxic to mammalian cells; however, some types, such as murine inner medullary collecting duct cells, are normally exposed to high-salt media. The IMCD3 cell line, derived from this mouse kidney cell type, is able to survive and even proliferate under high-salt conditions after a short period of adaptation (1 ...
Christophe E, Redon, William M, Bonner
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Repair of DNA Double-Strand Breaks in Heterochromatin [PDF]
Biomolecules, 2016 DNA double-strand breaks (DSBs) are among the most damaging lesions in DNA, since, if not identified and repaired, they can lead to insertions, deletions or chromosomal rearrangements. DSBs can be in the form of simple or complex breaks, and may be repaired by one of a number of processes, the nature of which depends on the complexity of the break or ...
openaire +3 more sources
Quantitative Insights into Age-Associated DNA-Repair Inefficiency in Single Cells
Cell Reports, 2019 Summary: Although double-strand break (DSB) repair is essential for a cell’s survival, little is known about how DSB repair mechanisms are affected by age.
Thomas Z. Young +3 more
doaj +1 more source
Ubiquitin and ubiquitin-like molecules in DNA double strand break repair
Cell & Bioscience, 2020 Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential ...
Jia Yu, Bo Qin, Zhenkun Lou
doaj +1 more source
The ubiquitin landscape at DNA double-strand breaks [PDF]
Journal of Cell Biology, 2009 The intimate relationship between DNA double-strand break (DSB) repair and cancer susceptibility has sparked profound interest in how transactions on DNA and chromatin surrounding DNA damage influence genome integrity. Recent evidence implicates a substantial commitment of the cellular DNA damage response machinery to the synthesis, recognition, and ...
Messick, Troy E., Greenberg, Roger A.
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Proteins pinpoint double strand breaks
eLife, 2013 Combining green fluorescent protein with a protein that only binds to double strand breaks in DNA allows these breaks—which are an important form of DNA damage—to be detected with high efficiency in living bacteria.
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source