Results 51 to 60 of about 89,922 (309)

Double-strand break formation and repair.

, 2019
Double-strand break formation and repair.
Kexi Yi (6714749), Elizabeth Hemenway (6714746), Zulin Yu (648652), Stacie E. Hughes (210282), R. Scott Hawley (32329), Fengli Guo (258342)   +5 more
core   +1 more source

Heavy Metal Exposure Influences Double Strand Break DNA Repair Outcomes.

PLoS ONE, 2016
Heavy metals such as cadmium, arsenic and nickel are classified as carcinogens. Although the precise mechanism of carcinogenesis is undefined, heavy metal exposure can contribute to genetic damage by inducing double strand breaks (DSBs) as well as ...
Maria E Morales, Rebecca S Derbes, Catherine M Ade, Jonathan C Ortego, Jeremy Stark, Prescott L Deininger, Astrid M Roy-Engel   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Use of a unique reporter cassette to examine 5´ to 3´ resection at a site specific DNA double-strand break during meiosis [PDF]

, 2006
Meiotic recombination in Saccharomyces cerevisiae is initiated by the formation of DNA double strand breaks (DSBs), which are created by Spoil protein.
Bishop-Bailey, Anna
core  

Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier [PDF]

, 2011
Most DNA double-strand breaks (DSBs) in S- and G2-phase cells are repaired accurately by Rad51-dependent sister chromatid recombination. However, a minority give rise to gross chromosome rearrangements (GCRs), which can result in disease/death.
Ledesma, Jennifer, Whitby, Matthew C., Castagnetti, S, Sofueva, Sevil, Alexander Lorenz, Steinacher, R, Fekret Osman, Lorenz, Alexander, Sofueva, S, Ledesma, J, Castagnetti, Stefania, Whitby, Matthew, Steinacher, Roland, Sevil Sofueva, Stefania Castagnetti, Osman, F, Lorenz, A, Matthew C. Whitby, Whitby, MC, Osman, Fekret, Roland Steinacher, Jennifer Ledesma   +21 more
core   +1 more source

LigD: A Structural Guide to the Multi-Tool of Bacterial Non-Homologous End Joining

Frontiers in Molecular Biosciences, 2021
DNA double-strand breaks are the most lethal form of damage for living organisms. The non-homologous end joining (NHEJ) pathway can repair these breaks without the use of a DNA template, making it a critical repair mechanism when DNA is not replicating ...
Benhur Amare, Anthea Mo, Noorisah Khan, Dana J. Sowa, Dana J. Sowa, Monica M. Warner, Monica M. Warner, Andriana Tetenych, Andriana Tetenych, Sara N. Andres, Sara N. Andres   +10 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity. [PDF]

, 2012
The recruitment kinetics of double-strand break (DSB) signaling and repair proteins Mdc1, 53BP1 and Rad52 into radiation-induced foci was studied by live-cell fluorescence microscopy after ion microirradiation.
Hilmar Strickfaden (148181), Guenther Dollinger, Brüning, Tino, Anja Derer, Judith Seel (148178), Volker Hable, Derer, Anja, Guido A Drexler, Burgdorf, Christian, Tino Brüning, Drexler, Guido A., Dollinger, Günther, Friedl, Anna A., Christoph Greubel, Greubel, Christoph, Thomas Cremer, Christian Burgdorf, Guido A. Drexler (148161), Christian Burgdorf (148169), Hable, Volker, Tino Brüning (148165), Hilmar Strickfaden, Judith Seel, Christoph Greubel (148173), Thomas Cremer (93), Günther Dollinger (148186), Anna A Friedl, Cremer, Thomas, Guido A. Drexler, Anna A. Friedl, Anja Derer (148175), Strickfaden, Hilmar, Günther Dollinger, Anna A. Friedl (148183), Seel, Judith, Volker Hable (148157)   +35 more
core   +1 more source

A CRISPR-based assay for the study of eukaryotic DNA repair onboard the International Space Station.

PLoS ONE, 2021
As we explore beyond Earth, astronauts may be at risk for harmful DNA damage caused by ionizing radiation. Double-strand breaks are a type of DNA damage that can be repaired by two major cellular pathways: non-homologous end joining, during which ...
Sarah Stahl-Rommel, David Li, Michelle Sung, Rebecca Li, Aarthi Vijayakumar, Kutay Deniz Atabay, G Guy Bushkin, Christian L Castro, Kevin D Foley, D Scott Copeland, Sarah L Castro-Wallace, Ezequiel Alvarez Saavedra, Emily J Gleason, Sebastian Kraves   +13 more
doaj   +1 more source

Repair of Double-Strand Breaks by End Joining [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Nonhomologous end joining (NHEJ) refers to a set of genome maintenance pathways in which two DNA double-strand break (DSB) ends are (re)joined by apposition, processing, and ligation without the use of extended homology to guide repair. Canonical NHEJ (c-NHEJ) is a well-defined pathway with clear roles in protecting the integrity of chromosomes when ...
Kishore K, Chiruvella, Zhuobin, Liang, Thomas E, Wilson   +2 more
openaire   +2 more sources